Differentiation of tumor versus peritumoral cortex in gliomas by intraoperative electrocorticography.

IF 13.4 1区 医学 Q1 CLINICAL NEUROLOGY
Belén Díaz-Fernández, David Henao-Herreno, Juan Nieto, Alesya Evstratova, Silvia Cases-Cunillera, Louise Deboeuf, Alexandre Roux, Edouard Dezamis, Marc Zanello, Bertrand Mathon, Carine Karachi, Alexandre Carpentier, Pascale Varlet, Johan Pallud, Laurent Capelle, Catalina Alvarado-Rojas, Michel Le Van Quyen, Gilles Huberfeld
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引用次数: 0

Abstract

Background: Brain diffuse gliomas are highly epileptic and infiltrative tumors. Glioma surgery consists of the resection of the tumor core and the maximum of the peritumoral zone, infiltrated by tumor cells, guided by the intraoperative assessment of brain functionality and connectivity. However, its electrophysiological characteristics are poorly characterized.

Methods: We studied the characteristics of electrocorticographic (ECoG) signals, in the context of glioma surgery in awake conditions on 29 patients, using EEG activity sampled on the tumor itself versus on its borders and in healthy areas. We assessed the features of frequency bands and aperiodic components (offset and slope) of ECoG power spectra during awake glioma surgery, according to cortical tumoral versus peritumoral and healthy status.

Results: We found that tumor contacts present a decrease in activity for all the frequency bands except for delta activity, which was increased. Second, the peritumoral cortex was characterized by an increase in relative beta activity and slopes between 20 and 40 Hz. Low cortical tumor cell infiltration was directly correlated with a reduction in the production of physiological brain rhythms. Finally, an automatic classifier based on neural networks allowed the classification of the electrodes based on their power spectrum characteristics.

Conclusions: This intraoperative study shows that ECoG during glioma surgery in awake condition may characterize the peritumoral cortices, key for pathophysiology and therapy, and deepens our knowledge of the effects of tumor cell infiltration on nervous tissue activity. Its assessment during the surgical procedure should better delineation of the cortical areas to be removed.

通过术中皮质电图区分胶质瘤的肿瘤与瘤周皮质
背景:脑弥漫性胶质瘤是高度癫痫性和浸润性肿瘤。胶质瘤手术包括切除肿瘤核心和最大限度地切除肿瘤细胞浸润的瘤周区,并以术中对脑功能和连接性的评估为指导。然而,其电生理特征却鲜为人知:我们研究了 29 名患者在清醒状态下进行胶质瘤手术时的脑电图(ECoG)信号特征,使用的脑电图活动取样点是肿瘤本身、肿瘤边界和健康区域。我们根据皮质肿瘤与瘤周和健康状况,评估了清醒状态下胶质瘤手术期间心电图功率谱的频带和非周期性成分(偏移和斜率)的特征:结果:我们发现,除δ活动增加外,肿瘤接触点所有频段的活动均减少。其次,瘤周皮质的特点是相对β活动和20-40赫兹之间的斜率增加。皮层肿瘤细胞浸润程度低与大脑生理节律产生的减少直接相关。最后,基于神经网络的自动分类器可根据功率谱特征对电极进行分类:这项术中研究表明,在清醒状态下进行胶质瘤手术时的心电图可描述瘤周皮质的特征,这是病理生理学和治疗的关键,并加深了我们对肿瘤细胞浸润对神经组织活动影响的认识。在手术过程中对其进行评估,可以更好地划分需要切除的皮质区域。
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来源期刊
Neuro-oncology
Neuro-oncology 医学-临床神经学
CiteScore
27.20
自引率
6.30%
发文量
1434
审稿时长
3-8 weeks
期刊介绍: Neuro-Oncology, the official journal of the Society for Neuro-Oncology, has been published monthly since January 2010. Affiliated with the Japan Society for Neuro-Oncology and the European Association of Neuro-Oncology, it is a global leader in the field. The journal is committed to swiftly disseminating high-quality information across all areas of neuro-oncology. It features peer-reviewed articles, reviews, symposia on various topics, abstracts from annual meetings, and updates from neuro-oncology societies worldwide.
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