Synthetic DWI: contrast improvement for diffusion-weighted imaging in prostate using T1 shine-through by synthesizing images with adjusted TR and TE.

IF 2 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2025-03-24 DOI:10.1007/s10334-025-01243-5

Yu Ueda, Tsutomu Tamada, Atsushi Higaki, Ayumu Kido, Hiroyasu Sanai, Kazunori Moriya, Taro Takahara, Makoto Obara, Marc Van Cauteren

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引用次数: 0

Abstract

Objective: To investigate whether synthetic DWI (SyDWI) calculated with short TR and zero TE can improve diffusion contrast in prostate compared to conventional DWI acquired with standard TR and TE.

Materials and methods: Thirty-two patients who underwent multiparametric MRI (mp-MRI) on a 3.0 T scanner were enrolled. For SyDWI, DWIs at b0 were acquired with two different TRs and TEs in addition to b1000 and b2000 images acquired with single conventional TR and TE. Contrast ratio (CR) was compared between SyDWI calculated with TR of 1000 ms and TE of 0 ms and conventional DWI acquired with TR of 6000 ms and TE of 70 ms.

Results: The mean CR between prostate cancer (PCa) and normal prostate, and between PCa and benign prostatic hyperplasia (BPH), is significantly higher in SyDWI compared to conventional DWI for both b-values of 1000 and 2000 s/mm². In addition, contrast within some lesions is now visualized, suggesting that tumour heterogeneity can be observed that is not seen with conventional DWI.

Conclusion: SyDWI calculated with TR of 1000 ms and TE of 0 ms significantly improves diffusion contrast between PCa and normal prostate or BPH, and within the lesion, compared to conventional DWI as a result of T1 shine-through.

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合成DWI：通过调整后的TR和TE合成图像，提高T1透照前列腺弥散加权成像的对比度。

目的：探讨短TR和零TE计算的合成DWI （SyDWI）与标准TR和TE获得的常规DWI相比，是否能改善前列腺弥散造影。材料和方法：32例患者在3.0 T扫描仪上接受了多参数MRI （mp-MRI）检查。对于SyDWI，除了使用单一常规TR和TE获取b1000和b2000图像外，还使用两种不同的TR和TE获取b0的dwi。将TR为1000 ms、TE为0 ms的SyDWI与TR为6000 ms、TE为70 ms的常规DWI进行对比。结果：前列腺癌（PCa）与正常前列腺之间、前列腺癌与良性前列腺增生（BPH）之间的平均CR在b值为1000 s/mm2和2000 s/mm2时均明显高于常规DWI。此外，现在可以看到一些病变内的对比，表明可以观察到传统DWI无法观察到的肿瘤异质性。结论：与T1透照的常规DWI相比，TR为1000 ms， TE为0 ms计算的SyDWI明显改善了前列腺癌与正常前列腺或BPH之间以及病变内的弥散对比。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnetic Resonance Materials in Physics, Biology and Medicine 医学-核医学

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include: advances in materials, hardware and software in magnetic resonance technology, new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine, study of animal models and intact cells using magnetic resonance, reports of clinical trials on humans and clinical validation of magnetic resonance protocols.