Discussion on the effects of Chinese medicine processing on the changes of medicinal properties based on the changes of chemical constituents and pharmacodynamic perspective.
Wang Ya-Zhu, Wang Xiao-Ting, Tian Shu-Qing, Jia Tian-Zhu, Gao Hui
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引用次数: 0
Abstract
Ethnopharmacology relevance: The theory of medicinal properties in Traditional Chinese Medicine (TCM) has a long history and serves as the foundation and core of TCM's theoretical system. It plays an irreplaceable role in guiding clinical medication and enhancing therapeutic efficacy. TCM processing is a traditional technology for processing and treating Chinese medicinal materials, which is a major characteristic of clinical TCM practice. Through processing, the chemical components and pharmacological effects of Chinese medicinal materials will change, manifested as changes in several aspects of their medicinal properties. These changes lead to corresponding alterations in their therapeutic functions and clinical applications, enabling them to meet diverse clinical needs for treating various diseases and conditions.
Aims of the study: This study begins with an exploration of ancient books on the relationship between TCM processing and medicinal properties. It aims to provide a modern scientific basis for clarifying how processing affects TCM's medicinal properties, while offering a systematic interpretation of traditional theories through the lens of chemical composition and pharmacological changes.
Materials and methods: We collected and analyzed relevant articles from different scientific databases regarding TCM processing and medicinal properties theory. By concentrating on well-studied TCM varieties as representatives, the effects of processing on the changes of medicinal properties of TCM were explained by examples from the perspective of chemical composition and pharmacodynamic changes.
Results: The findings of this study indicate that analyzing the impact of TCM processing on its medicinal properties not only enhances the application of TCM but also serves as a crucial reference for the development of new pharmaceuticals. In addition, the study reveals the complexity of the changes in the characteristics of TCM, which brings new challenges and opportunities for further research. Especially in the perspective of modern pharmacology, in-depth study of the relationship between the processing of TCM and its efficacy will provide a scientific basis for the standardization and normalization of TCM.
Conclusion: This study enriches the theoretical framework of TCM processing and establishes an empirical foundation for optimizing its clinical use. We hope that these findings will stimulate further research, so as to promote the modernization of TCM, which will lay a more solid foundation for the scientific research and clinical application of TCM.
期刊介绍：
The Journal of Ethnopharmacology is dedicated to the exchange of information and understandings about people''s use of plants, fungi, animals, microorganisms and minerals and their biological and pharmacological effects based on the principles established through international conventions. Early people confronted with illness and disease, discovered a wealth of useful therapeutic agents in the plant and animal kingdoms. The empirical knowledge of these medicinal substances and their toxic potential was passed on by oral tradition and sometimes recorded in herbals and other texts on materia medica. Many valuable drugs of today (e.g., atropine, ephedrine, tubocurarine, digoxin, reserpine) came into use through the study of indigenous remedies. Chemists continue to use plant-derived drugs (e.g., morphine, taxol, physostigmine, quinidine, emetine) as prototypes in their attempts to develop more effective and less toxic medicinals.
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