{"title":"A challenging diagnosis of malignant peritoneal mesothelioma.","authors":"Marco Soncini, Mishel Malethi Wanasinghe Arachchige, Chiara Frigerio, Lara Verdi, Ruben Bordoli","doi":"10.1007/s11739-025-03919-1","DOIUrl":null,"url":null,"abstract":"<p><p>Malignant Peritoneal Mesothelioma (MPM) is a rare and aggressive cancer originating in the mesothelial serosal membranes, often associated with pleural mesothelioma. Its diagnosis is challenging due to its nonspecific symptoms, such as abdominal distension, pain, weight loss, and ascites, which overlap with other abdominal conditions. This case study details a 64-year-old male patient with a complex clinical presentation, initially misdiagnosed with seronegative celiac disease, before ultimately being diagnosed with MPM through video-laparoscopy. Despite extensive workup-including CT, PET scans, and colonoscopy-the diagnosis was delayed until peritoneal nodules were identified. MPM remains difficult to detect, often identified at advanced stages, with a poor prognosis and a median survival of less than 1 year post-diagnosis. This case underscores the importance of a comprehensive diagnostic approach, particularly in patients with nonspecific abdominal symptoms, to improve early detection and treatment outcomes for MPM.</p>","PeriodicalId":13662,"journal":{"name":"Internal and Emergency Medicine","volume":" ","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Internal and Emergency Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11739-025-03919-1","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Malignant Peritoneal Mesothelioma (MPM) is a rare and aggressive cancer originating in the mesothelial serosal membranes, often associated with pleural mesothelioma. Its diagnosis is challenging due to its nonspecific symptoms, such as abdominal distension, pain, weight loss, and ascites, which overlap with other abdominal conditions. This case study details a 64-year-old male patient with a complex clinical presentation, initially misdiagnosed with seronegative celiac disease, before ultimately being diagnosed with MPM through video-laparoscopy. Despite extensive workup-including CT, PET scans, and colonoscopy-the diagnosis was delayed until peritoneal nodules were identified. MPM remains difficult to detect, often identified at advanced stages, with a poor prognosis and a median survival of less than 1 year post-diagnosis. This case underscores the importance of a comprehensive diagnostic approach, particularly in patients with nonspecific abdominal symptoms, to improve early detection and treatment outcomes for MPM.
期刊介绍：
Internal and Emergency Medicine (IEM) is an independent, international, English-language, peer-reviewed journal designed for internists and emergency physicians. IEM publishes a variety of manuscript types including Original investigations, Review articles, Letters to the Editor, Editorials and Commentaries. Occasionally IEM accepts unsolicited Reviews, Commentaries or Editorials. The journal is divided into three sections, i.e., Internal Medicine, Emergency Medicine and Clinical Evidence and Health Technology Assessment, with three separate editorial boards. In the Internal Medicine section, invited Case records and Physical examinations, devoted to underlining the role of a clinical approach in selected clinical cases, are also published. The Emergency Medicine section will include a Morbidity and Mortality Report and an Airway Forum concerning the management of difficult airway problems. As far as Critical Care is becoming an integral part of Emergency Medicine, a new sub-section will report the literature that concerns the interface not only for the care of the critical patient in the Emergency Department, but also in the Intensive Care Unit. Finally, in the Clinical Evidence and Health Technology Assessment section brief discussions of topics of evidence-based medicine (Cochrane’s corner) and Research updates are published. IEM encourages letters of rebuttal and criticism of published articles. Topics of interest include all subjects that relate to the science and practice of Internal and Emergency Medicine.
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