Patients with endometriosis in the vagina, bowel, or bladder experience a prolonged diagnostic delay: an observational study.

IF 6 1区 医学 Q1 OBSTETRICS & GYNECOLOGY
M E Madsen, D Hartwell, L K A Kähler, L Dyrved, B H Ejsing, L E Vexø, S E Thomassen, M C Havemann, A E Sakse, K Røssaak, M Nyegaard, H S Nielsen
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引用次数: 0

Abstract

Study question: Do the diagnostic delay and symptoms differ between endometriosis patients with advanced disease, defined as endometriosis involving the vagina, intestine, rectovaginal septum, or bladder (eVIRB), compared to patients without endometriosis in these locations (non-eVIRB)?

Summary answer: Patients with advanced endometriosis had a significantly longer diagnostic delay, an earlier onset of symptoms, and more intense pain during menstruation.

What is known already: Endometriosis patients often experience years of symptoms before diagnosis. Whether there is an association between the length of this diagnostic delay and advanced disease remains unclear. Confirming such an association would underscore the importance of early diagnosis to ensure appropriate treatment, which may reduce the risk of irreversible organ damage and high-risk surgery for patients.

Study design, size, duration: This is an observational cohort study of 129 patients undergoing endometriosis surgery conducted over a 3-year period. The first patient was operated on in November 2019. All patients reported retrospective questionnaire data, and surgeons described surgical findings.

Participants/materials, setting, methods: The patients were operated on for predominantly moderate to severe endometriosis at a Tertiary Endometriosis Centre in Denmark. The diagnostic delay was calculated from questionnaire data and related to intraoperative findings. Selected symptoms were compared.

Main results and the role of chance: The median diagnostic delay was 5 years. However, the patients with eVIRB (n = 75) experienced a significantly longer median diagnostic delay of 9 years compared to non-eVIRB patients (n = 54), who had a median delay of only 2 years (P = 0.005). The odds ratio of having eVIRB was 5-fold (95% CI 2.18-11.61, P < 0.001) increased if the diagnostic delay exceeded 5 years, and they reported a significantly earlier onset of endometriosis symptoms. Both groups reported numerous pain symptoms, with a significant difference observed only in responses regarding severe period cramps requiring bed rest and use of painkillers. The eVIRB group had used hormones significantly longer and had taken painkillers more regularly due to pelvic pain.

Limitations, reasons for caution: The retrospective data may be affected by recall bias. This study describes associations between a prolonged diagnostic delay and advanced disease, not causality.

Wider implications of the findings: This study is the first to describe an association between advanced endometriosis and a prolonged diagnostic delay after adjusting for total years of hormonal use and age at surgery. Future research should concentrate on strategies to achieve earlier diagnosis for patients presenting with this advanced form of the disease, given the potential for severe complications.

Study funding/competing interest(s): Ferring Pharmaceuticals (MiHSN01) and partial funding from The European Union's Horizon 2020 research and innovation programme (No. 101017562). None of the funders was involved in the study design, data collection, analysis, writing of this paper, or the decision to submit it for publication. H.S.N. reports speakers' fees from Ferring Pharmaceuticals, Merck Denmark A/S, IBSA Nordic, AstraZeneca, Cook Medical, Gedeon Richter, and Novo Nordisk outside the submitted work. No other conflicts are reported.

Trial registration number: N/A.

研究问题晚期子宫内膜异位症是指累及阴道、肠道、直肠阴道隔或膀胱的子宫内膜异位症(eVIRB),与这些部位没有子宫内膜异位症的患者(非eVIRB)相比,晚期子宫内膜异位症患者的诊断延迟和症状是否有所不同?晚期子宫内膜异位症患者的诊断延迟时间明显更长,症状出现得更早,月经期间的疼痛更剧烈:已知信息:子宫内膜异位症患者在确诊前往往已出现多年症状。这种诊断延迟的时间长短与疾病晚期之间是否存在关联仍不清楚。研究设计、规模、持续时间:这是一项观察性队列研究:这是一项观察性队列研究,对129名接受子宫内膜异位症手术的患者进行了为期3年的观察。首例患者于 2019 年 11 月接受手术。所有患者均报告了回顾性问卷数据,外科医生描述了手术结果:患者主要因中度至重度子宫内膜异位症在丹麦一家三级子宫内膜异位症中心接受手术。诊断延迟根据问卷数据计算,并与术中发现相关。对选定的症状进行了比较:诊断延迟的中位数为 5 年。然而,与非 eVIRB 患者(n = 54)相比,eVIRB 患者(n = 75)的中位诊断延迟时间明显更长,达到 9 年,而非 eVIRB 患者的中位延迟时间仅为 2 年(P = 0.005)。患有 eVIRB 的几率比为 5 倍(95% CI 2.18-11.61, P 局限性,需谨慎的原因:回顾性数据可能会受到回忆偏差的影响。本研究描述的是诊断延迟时间过长与疾病晚期之间的关联,而非因果关系:本研究首次描述了在对使用激素的总年数和手术年龄进行调整后,子宫内膜异位症晚期与诊断延迟时间过长之间的关系。考虑到晚期子宫内膜异位症可能引发严重并发症,未来的研究应集中在为晚期子宫内膜异位症患者制定更早的诊断策略上:Ferring制药公司(MiHSN01)和欧盟 "地平线2020 "研究与创新计划(编号101017562)的部分资助。所有资助者均未参与研究设计、数据收集、分析、本文撰写或决定是否将本文提交发表。H.S.N.报告了Ferring Pharmaceuticals、Merck Denmark A/S、IBSA Nordic、AstraZeneca、Cook Medical、Gedeon Richter和Novo Nordisk在所提交工作之外的演讲费。未报告其他冲突。试验注册号:不适用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Human reproduction
Human reproduction 医学-妇产科学
CiteScore
10.90
自引率
6.60%
发文量
1369
审稿时长
1 months
期刊介绍: Human Reproduction features full-length, peer-reviewed papers reporting original research, concise clinical case reports, as well as opinions and debates on topical issues. Papers published cover the clinical science and medical aspects of reproductive physiology, pathology and endocrinology; including andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, early pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues.
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