Just 1-min exposure to a pure tone at 100 Hz with daily exposable sound pressure levels may improve motion sickness.

IF 4 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Environmental Health and Preventive Medicine Pub Date : 2025-01-01 DOI:10.1265/ehpm.24-00247

Yishuo Gu, Nobutaka Ohgami, Tingchao He, Takumi Kagawa, Fitri Kurniasari, Keming Tong, Xiang Li, Akira Tazaki, Kodai Takeda, Masahiro Mouri, Masashi Kato

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Abstract

Background: Motion sickness is a common transportation issue worldwide. Vestibular dysfunction has been reported to be a key etiology of motion sickness. However, there are limited technologies for alleviating motion sickness.

Methods: The most appropriate frequency (Hz) and level (dBZ) of pure tone for modulation of vestibular function were determined by an ex vivo study using murine utricle explants. The preventive effects of the selected pure tone on motion sickness were then confirmed by using a beam balance test in mice. The alleviating effects of pure tone on motion sickness induced by a swing, driving simulator or real car were objectively assessed by using posturography and electrocardiography (ECG) and were subjectively assessed by using the Motion Sickness Assessment Questionnaire (MSAQ) in humans.

Results: The effect of short-term (≤5 min) exposure to a pure tone of 80-85 dBZ (= 60.9-65.9 dBA) at 100 Hz on motion sickness was investigated in mice and humans. A mouse study showed a long-lasting (≥120 min) alleviative effect on shaking-mediated exacerbated beam test scores by 5-min exposure to a pure tone of 85 dBZ at 100 Hz, which was ex vivo determined as a sound activating vestibular function, before shaking. Human studies further showed that 1-min exposure to a pure tone of 80-85 dBZ (= 60.9-65.9 dBA) at 100 Hz before shaking improved the increased envelope areas in posturography caused by the shakings of a swing, a driving simulator and a vehicle. Driving simulator-mediated activation of sympathetic nerves assessed by the heart rate variable (HRV) and vehicle-mediated increased scores of the MSAQ were improved by pure tone exposure before the shaking.

Conclusion: Since the exacerbated results of posturography and HRV reflect shaking-mediated imbalance and autonomic dysfunction, respectively, the results suggest that the imbalance and autonomic dysregulation in motion sickness could be improved by just 1-min exposure to a pure tone with daily exposable sound pressure levels.

Trial registration: Registration number: UMIN000022413 (2016/05/23-2023/04/19) and UMIN000053735 (2024/02/29-present).

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仅在100赫兹的纯音中暴露1分钟，每天暴露的声压水平可能会改善晕动病。

背景：晕动病是世界范围内常见的交通问题。据报道，前庭功能障碍是晕动病的一个关键病因。然而，缓解晕动病的技术有限。方法：采用离体研究方法，以小鼠前庭神经细胞为外植体，确定调节前庭神经功能的最适宜纯音频率（Hz）和水平（dBZ）。选择的纯音对晕动病的预防作用，然后通过在小鼠中使用光束平衡测试来证实。采用体位法和心电图法客观评价纯音对摇摆车、模拟驾驶车和真车引起的晕动病的缓解效果，主观上采用运动病评估问卷（MSAQ）评价纯音对人体晕动病的缓解效果。结果：研究了短期（≤5分钟）暴露在100 Hz的80-85 dBZ （= 60.9-65.9 dBA）纯音环境下对小鼠和人类晕动病的影响。一项小鼠研究表明，在震动前，暴露于85 dBZ的100 Hz纯音5分钟，对震动介导的加重波束测试成绩有持久（≥120分钟）的缓解作用，这是体外确定的声音激活前庭功能。人体研究进一步表明，在震动之前，在100赫兹下接触80-85 dBZ （= 60.9-65.9 dBA）的纯音1分钟，可以改善由秋千、驾驶模拟器和车辆震动引起的姿势学中增加的包络面积。通过心率变量（HRV）评估的驾驶模拟器介导的交感神经激活和车辆介导的MSAQ分数增加，在摇晃前的纯音暴露得到改善。结论：由于体位摄影和HRV加重的结果分别反映了震动介导的不平衡和自主神经功能障碍，结果表明，在每天暴露声压水平的纯音下暴露1分钟即可改善运动病的不平衡和自主神经失调。试验报名：注册号：UMIN000022413（2016/05/23-2023/04/19）和UMIN000053735（2014/02/29至今）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Health and Preventive Medicine PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -

CiteScore

7.90

自引率

2.10%

发文量

审稿时长

10 weeks

期刊介绍： The official journal of the Japanese Society for Hygiene, Environmental Health and Preventive Medicine (EHPM) brings a comprehensive approach to prevention and environmental health related to medical, biological, molecular biological, genetic, physical, psychosocial, chemical, and other environmental factors. Environmental Health and Preventive Medicine features definitive studies on human health sciences and provides comprehensive and unique information to a worldwide readership.