Classic Psychedelics for the Treatment of Depression: Potential Benefits and Challenges.

IF 13 1区医学 Q1 PHARMACOLOGY & PHARMACY

Drugs Pub Date : 2025-05-01 Epub Date: 2025-03-24 DOI:10.1007/s40265-025-02172-2

Sharmin Ghaznavi, Sarah G Richter

引用次数: 0

Abstract

There has been a recent resurgence in research on psychedelics as therapeutic agents for psychiatric conditions. This leading article outlines the studies to date of classic psychedelic treatments for treatment-resistant depression and major depression, including psilocybin, ayahuasca, dimethyltryptamine (DMT), and O-methyl-bufotenine (5-Me-O DMT). We discuss the potential of expanding treatment options for depression based on the data available, as well as the difficulties and limitations of research on psychedelics that make assessing that potential more challenging.

查看原文本刊更多论文

经典迷幻药治疗抑郁症：潜在的好处和挑战。

最近，将致幻剂作为精神疾病的治疗剂的研究重新兴起。这篇主要文章概述了迄今为止对难治性抑郁症和重度抑郁症的经典迷幻治疗的研究，包括裸盖菇素、死藤水、二甲基色胺（DMT）和o -甲基丁烯酮（5-Me-O DMT）。我们根据现有的数据讨论了扩大抑郁症治疗方案的潜力，以及迷幻药研究的困难和局限性，这使得评估这种潜力更具挑战性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Drugs 医学-毒理学

CiteScore

22.70

自引率

0.90%

发文量

134

审稿时长

3-8 weeks

期刊介绍： Drugs is a journal that aims to enhance pharmacotherapy by publishing review and original research articles on key aspects of clinical pharmacology and therapeutics. The journal includes: Leading/current opinion articles providing an overview of contentious or emerging issues. Definitive reviews of drugs and drug classes, and their place in disease management. Therapy in Practice articles including recommendations for specific clinical situations. High-quality, well designed, original clinical research. Adis Drug Evaluations reviewing the properties and place in therapy of both newer and established drugs. AdisInsight Reports summarising development at first global approval. Moreover, the journal offers additional digital features such as animated abstracts, video abstracts, instructional videos, and podcasts to increase visibility and educational value. Plain language summaries accompany articles to assist readers with some knowledge of the field in understanding important medical advances.