Unraveling the Role of Tumor-infiltrating Immune Cells in Modulating Cancer Drug Resistance.

IF 2.6 4区医学 Q3 CHEMISTRY, MEDICINAL

Anti-cancer agents in medicinal chemistry Pub Date : 2025-03-24 DOI:10.2174/0118715206365310250310081445

Shima Mehrabadi

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引用次数: 0

Abstract

Tumor-infiltrating immune cells (TIICs) have been identified as critical components in the development of cancer drug resistance. This review aims to discuss the various types of TIICs, such as macrophages and T cells, that have been linked to cancer drug resistance. Furthermore, we explore the mechanisms by which TIICs contribute to drug resistance and how these mechanisms may differ across various tumor types. Additionally, we examine the potential of immune checkpoint inhibitors in combination with traditional cancer therapies as a strategy to overcome TIIC-mediated cancer drug resistance. In conclusion, this review provides an in-depth analysis of the current knowledge on the role of TIICs in cancer drug resistance and highlights potential avenues for future research to develop more effective treatment strategies. The findings presented in this review emphasize the importance of understanding the complex interactions between cancer cells and the immune system in order to develop novel therapeutic approaches that can overcome TIIC-mediated cancer drug resistance.

查看原文本刊更多论文

肿瘤浸润免疫细胞在调节肿瘤耐药中的作用。

肿瘤浸润免疫细胞（TIICs）已被确定为癌症耐药发展的关键组成部分。本文旨在讨论各种类型的TIICs，如巨噬细胞和T细胞，与癌症耐药有关。此外，我们探讨了TIICs促进耐药的机制，以及这些机制在不同肿瘤类型中可能存在的差异。此外，我们研究了免疫检查点抑制剂与传统癌症疗法联合使用的潜力，作为克服tic介导的癌症耐药的策略。总之，本综述对TIICs在癌症耐药中的作用进行了深入分析，并强调了未来研究开发更有效治疗策略的潜在途径。本综述的研究结果强调了了解癌细胞与免疫系统之间复杂相互作用的重要性，以便开发新的治疗方法，克服tiic介导的癌症耐药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anti-cancer agents in medicinal chemistry ONCOLOGY-CHEMISTRY, MEDICINAL

CiteScore

5.10

自引率

3.60%

发文量

323

审稿时长

4-8 weeks

期刊介绍： Formerly: Current Medicinal Chemistry - Anti-Cancer Agents. Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents. Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication. Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.