Olivia Pierog, Taylor Craig, Jacky Jennings, Michael J Borowitz, Ananya Munjal, Mariah Owusu-Agyei, David Weiner, J David Peske, Suman Paul, Sima Rozati
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引用次数: 0
Abstract
Identifying aberrant T lymphocytes in peripheral blood is essential for diagnosing Sezary syndrome (SS) and is a prognostic indicator in mycosis fungoides (MF). Flow cytometry using a T-cell receptor constant beta-1 chain (TRBC1)-targeting antibody provides a refined approach for detecting T-cell clonality. We evaluated the performance of the TRBC1 antibody assay (TRBC1-aa) in 164 patients, compared to standard flow cytometry methods for assessing T-cell aberrancy, demonstrating 92.3% sensitivity and 83.5% specificity. TRBC1-aa accurately excluded clonality in 100% of benign inflammatory dermatoses and improved the detection of residual blood involvement earlier than standard flow cytometry in 66.7% of SS and 25.0% of advanced-stage MF patients on systemic therapy.
期刊介绍：
The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.
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