Shashikala Mariswamy Rajesh, Prasanna Doddakunche Shivaramu, Chandra Sekhar Bhol, Toreshettahally R. Swaroop, Habbanakuppe D. Preetham, Rajaghatta N. Suresh, Arunachalam Chinnathambi, Chandramohan Govindasamy, Sulaiman Ali Alharbi, Veeresha Gowda Shalini, Kwang Seok Ahn, Shobith Rangappa, Kanchugarakoppal S. Rangappa
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引用次数: 0
Abstract
Epoxides are well-known compounds as anticancer agents. In this article, we present the synthesis of novel 3′-phenyl-1-((1-aryl-1H-1,2,3-triazol-5-yl)methyl)spiro[indoline-3,2′-oxiran]-2-one derivatives by the regioselective reaction of sulfur ylides with 1,2,3-triazole-tethered isatins and their anticancer effects on hepatocellular carcinoma (HCC) cells HepG2 and HCCLM3. The cell viability assays indicated that RR-01 and RR-07 had emerged as the most potent cytotoxic agents on the tested cell lines. Colony formation and migration assay results confirmed the anticancer effects of these compounds by inhibiting the formation of colonies and migration. Further, nuclear fragmentation staining assay showed that the compounds induce apoptosis. Acridine orange staining assays showed that our lead candidates (RR-01 and RR-07) induced autophagy in liver cancer cells.
期刊介绍：
Chemical Biology & Drug Design is a peer-reviewed scientific journal that is dedicated to the advancement of innovative science, technology and medicine with a focus on the multidisciplinary fields of chemical biology and drug design. It is the aim of Chemical Biology & Drug Design to capture significant research and drug discovery that highlights new concepts, insight and new findings within the scope of chemical biology and drug design.
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