Development of site- and stereoselective continuous flow deuterium labelling method for carbohydrates using high dispersion effect towards Ru/C of hydrogen flow†

IF 3.4 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Reaction Chemistry & Engineering Pub Date : 2025-03-11 DOI:10.1039/D5RE00026B

Naoya Sakurada, Daiki Sasaki, Manato Ono, Tsuyoshi Yamada, Takashi Ikawa and Hironao Sajiki

引用次数: 0

Abstract

A site- and stereoselective deuterium labelling method for carbohydrates has been developed using a Ru/C catalyst under continuous flow conditions. It has been demonstrated that enhancing the void fraction of the catalyst cartridge leads to improved incorporation, while maintaining high selectivity over 150 h. This scalable, sustainable approach has the potential to reduce energy use, waste and Ru consumption, thus broadening continuous flow applications in organic synthesis.

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利用氢流对Ru/C的高分散效应，建立了原位和立体选择性连续流碳水化合物氘标记方法

在连续流动条件下，采用Ru/C催化剂，建立了碳水化合物的位置和立体选择性氘标记方法。已经证明，提高催化剂盒的空隙率可以改善掺入，同时在150小时内保持高选择性。这种可扩展，可持续的方法有可能减少能源使用，浪费和Ru消耗，从而扩大有机合成中的连续流应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reaction Chemistry & Engineering Chemistry-Chemistry (miscellaneous)

CiteScore

6.60

自引率

7.70%

发文量

227

期刊介绍： Reaction Chemistry & Engineering is a new journal reporting cutting edge research into all aspects of making molecules for the benefit of fundamental research, applied processes and wider society. From fundamental, molecular-level chemistry to large scale chemical production, Reaction Chemistry & Engineering brings together communities of chemists and chemical engineers working to ensure the crucial role of reaction chemistry in today’s world.