Impact of Sorbs2 dysfunction on cardiovascular diseases

IF 4.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2025-03-24 DOI:10.1016/j.bbadis.2025.167813

Xiaowei Xiong, Hon-Chi Lee, Tong Lu

引用次数: 0

Abstract

Despite significant advancements in prevention and treatment over the past decades, cardiovascular diseases (CVDs) remain the leading cause of death worldwide. CVDs involve multifactorial inheritance, but our understanding of the genetic impact on these diseases is still incomplete. Sorbin and SH3 domain-containing protein 2 (Sorbs2) is ubiquitously expressed in various tissues, including the cardiovascular system. Increasing evidence suggests that Sorbs2 malfunction contributes to CVDs. This manuscript will review our current understanding of the potential mechanisms underlying Sorbs2 dysregulation in the development of CVDs.

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Sorbs2功能障碍对心血管疾病的影响

尽管过去几十年来在预防和治疗方面取得了重大进展，但心血管疾病仍然是全世界死亡的主要原因。心血管疾病涉及多因素遗传，但我们对这些疾病的遗传影响的理解仍然不完整。Sorbin和SH3结构域蛋白2 （Sorbs2）在包括心血管系统在内的多种组织中普遍表达。越来越多的证据表明Sorbs2功能障碍会导致心血管疾病。本文将回顾我们目前对心血管疾病发展中Sorbs2失调的潜在机制的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et biophysica acta. Molecular basis of disease 生物-生化与分子生物学

CiteScore

12.30

自引率

0.00%

发文量

218

审稿时长

32 days

期刊介绍： BBA Molecular Basis of Disease addresses the biochemistry and molecular genetics of disease processes and models of human disease. This journal covers aspects of aging, cancer, metabolic-, neurological-, and immunological-based disease. Manuscripts focused on using animal models to elucidate biochemical and mechanistic insight in each of these conditions, are particularly encouraged. Manuscripts should emphasize the underlying mechanisms of disease pathways and provide novel contributions to the understanding and/or treatment of these disorders. Highly descriptive and method development submissions may be declined without full review. The submission of uninvited reviews to BBA - Molecular Basis of Disease is strongly discouraged, and any such uninvited review should be accompanied by a coverletter outlining the compelling reasons why the review should be considered.