Assessment of fetal hepatic lipid content by magnetic resonance imaging and association of results with clinical maternal and fetal parameters

Abstract

Purpose

To quantify hepatocellular lipids in the fetal liver, we tested the feasibility of the multiecho mDixon Quant sequence (chemical shift encoded magnetic resonance imaging (MRI)) during clinically routine fetal whole-body MRI and investigated the correlation of hepatocellular lipids with different clinical maternal and fetal parameters.

Methods

The livers of 155 fetuses were prospectively investigated with multiecho CSE-MRI sequences during clinically indicated whole-body MRI, performed between gestational weeks 19 and 38 on a 1.5 Tesla scanner. The hepatocellular lipids were quantified by measuring the proton density fat fraction in the left and right liver lobe. Results of the right liver lobe were correlated with the maternal body mass index, maternal age, presence of maternal diabetes, gestational age at assessment, estimated fetal weight, fetal sex, and birth weight.

Results

Quantification of fetal hepatocellular lipids was feasible in 151/155 (97.4 %) fetuses. Four examinations were excluded due to strong motion artifacts and poor image quality. The proton density fat fraction values ranged from 0 % to 5.7 % (mean 2.26; SD 1.37). Hepatocellular lipids were associated with the presence of maternal diabetes (p = 0.027). No association was found between hepatocellular lipids and maternal body mass index (p = 0.306), maternal age (p = 0.582), gestational age (p = 0.456), estimated fetal weight (p = 0.176), fetal sex (p = 0.181), or birth weight (p = 0.957).

Conclusion

Quantification of fetal hepatocellular lipids is feasible and may routinely be performed during whole-body MRI to detect early liver fat accumulation, particularly in the presence of maternal diabetes.