Solvothermal Synthesis of Innovative and Efficient Ag/NA-MOF Nanoparticles for One-Pot Synthesis of Imidazoquinazolinones and In vitro Validation as Anti-Alzheimer Agents

Abstract

Nicotinic acid was presented as MOF-mediated in the hydrothermal synthesis of silver MOF nanoparticles followed by the crystallography study of its structure by IR, SEM, TEM, and XRD. The catalytic properties of the prepared Ag/NA-MOF were achieved in the synthesis of some new tetrahydrobenzo[4,5]imidazo[2,1-b]quinazolin-1(2H)-one derivatives through one pot mixing of dimedone, 2-aminobenzimidazole and aromatic aldehyde in the presence of catalytic amount of Ag/NA-MOF under solvent-free conditions. The synthesized tetracyclic imidazoquinazoline derivatives were binding ligands with acetylcholine esterase (AChE inhibitors). The in vitro validation approved the theoretical data through colorimetric determination of acetylcholinesterase activity. The data obtained explained that the compounds 4c, 4f, 4i and 4j give promising values and the most potent one is 4i by IC₅₀ value of 5.93 ± 0.02 μg/mL compared to the standard donepezil value of 5.18 ± 0.02 μg/mL as a reference Alzheimer's drug.