SARS-CoV-2 vaccination reduces the risk of thrombotic complications in severe COVID-19.

Medicina intensiva Pub Date : 2025-03-21 DOI:10.1016/j.medine.2025.502167

M Ángeles Alonso Fernández, Carola Bledig, Madian Manso Álvarez, Raquel Gómez Guardiola, Marina Blancas García, Irene Bartolomé, Manuel Quintana Díaz, Pilar Marcos Neira, Jose Alberto Silva Obregón, Ainhoa Serrano Lázaro, Salvador Campillo Morales, Blanca López Matamala, Carmen Martín Parra, Ángela Algaba Calderón, Rafael Blancas Gómez-Casero, Óscar Martínez González

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Abstract

Objectives: The aim of this study was to evaluate the association between SARS-CoV-2 vaccination and the occurrence of thrombotic complications in patients admitted to intensive care for severe COVID-19 pneumonia.

Design: Observational, descriptive, prospective, multicentre study.

Setting: Intensive care units of five university hospitals.

Patients: A total of 255 patients admitted to the intensive care unit (ICU) with SARS-CoV-2 pneumonia, confirmed by RT-PCR in throat swab or tracheal aspirate, starting the date the first vaccinated patient against SARS-CoV-2 was admitted in one of the participating ICUs, were included in the analysis.

Main variables of interest: Vaccination status against SARS-CoV-2 and thrombotic events.

Results: 18.8% of patients had received some form of vaccination. Thrombotic events occurred in 21.2% of patients. Lack of vaccination was associated with thrombotic events (OR 5.024; 95% CI: 1.104-23.123; p = 0.0037) and death (OR 5.161; 95% CI: 1.075-24.787; p = 0.04). ICU mortality was not associated with the occurrence of thrombotic complications.

Conclusions: In this series of patients, vaccination against SARS-CoV-2 reduced the risk of thrombotic events and mortality in patients with severe COVID-19 admitted to the ICU. Thrombotic complications did not alter ICU mortality.

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Medicina intensiva

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