Lipidomics and cardiovascular disease

IF 4.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2025-03-22 DOI:10.1016/j.bbadis.2025.167806

Arun Surendran , Hannah Zhang , Aleksandra Stamenkovic , Amir Ravandi

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引用次数: 0

Abstract

Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, necessitating innovative approaches for early detection and personalized interventions. Lipidomics, leveraging advanced mass spectrometry techniques, has become instrumental in deciphering lipid-mediated mechanisms in CVDs. This review explores the application of lipidomics in identifying biomarkers for myocardial infarction, heart failure, stroke, and calcific aortic valve stenosis (CAVS). This review examines the technological advancements in shotgun lipidomics and LC/MS, which provide unparalleled insights into lipid composition and function. Key lipid biomarkers, including ceramides and lysophospholipids, have been linked to disease progression and therapeutic outcomes. Integrating lipidomics with genomic and proteomic data reveals the molecular underpinnings of CVDs, enhancing risk prediction and intervention strategies. This review positions lipidomics as a transformative tool in reshaping cardiovascular research and clinical practice.

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脂质组学与心血管疾病。

心血管疾病（cvd）仍然是世界范围内导致死亡的主要原因，因此需要采用创新方法进行早期发现和个性化干预。脂质组学，利用先进的质谱技术，已经成为破译脂质介导的心血管疾病机制的工具。本文综述了脂质组学在鉴定心肌梗死、心力衰竭、中风和钙化主动脉瓣狭窄（CAVS）生物标志物方面的应用。本文综述了霰弹枪脂质组学和LC/MS的技术进展，这些技术为脂质的组成和功能提供了无与伦比的见解。关键的脂质生物标志物，包括神经酰胺和溶血磷脂，与疾病进展和治疗结果有关。将脂质组学与基因组和蛋白质组学数据相结合，揭示了心血管疾病的分子基础，增强了风险预测和干预策略。本综述将脂质组学定位为重塑心血管研究和临床实践的变革性工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et biophysica acta. Molecular basis of disease 生物-生化与分子生物学

CiteScore

12.30

自引率

0.00%

发文量

218

审稿时长

32 days

期刊介绍： BBA Molecular Basis of Disease addresses the biochemistry and molecular genetics of disease processes and models of human disease. This journal covers aspects of aging, cancer, metabolic-, neurological-, and immunological-based disease. Manuscripts focused on using animal models to elucidate biochemical and mechanistic insight in each of these conditions, are particularly encouraged. Manuscripts should emphasize the underlying mechanisms of disease pathways and provide novel contributions to the understanding and/or treatment of these disorders. Highly descriptive and method development submissions may be declined without full review. The submission of uninvited reviews to BBA - Molecular Basis of Disease is strongly discouraged, and any such uninvited review should be accompanied by a coverletter outlining the compelling reasons why the review should be considered.