Human Papillomavirus Testing in Head and Neck Carcinomas: Guideline Update.

James S Lewis, Beth Beadle, Justin A Bishop, Rebecca D Chernock, Carol Colasacco, Tanja Kalicanin, Jeffrey F Krane, Christina Lacchetti, Joel T Moncur, James W Rocco, Mary R Schwartz, Raja R Seethala, William C Faquin
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Abstract

Context.—: In 2018, an evidence-based guideline was published by the College of American Pathologists to develop recommendations for the testing, application, interpretation, and reporting of high-risk human papillomavirus and surrogate marker tests in head and neck carcinomas. Substantial new evidence has prompted a review, including data on human papillomavirus (HPV) in nonoropharyngeal anatomic sites, HPV global rates, p16 immunohistochemistry, and HPV testing performance in cytology specimens, and performance of p16 immunohistochemistry as a surrogate marker.

Objective.—: To assess research published since the release of the original 2018 guideline and to update evidence-based recommendations for HPV testing in head and neck carcinomas.

Design.—: The College of American Pathologists convened a panel of experts to update the guideline following the standards established by the National Academy of Medicine for developing trustworthy clinical practice guidelines. The expert panel defined the key questions and performed a systematic review of the literature. Using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, recommendations were updated on the basis of available evidence, certainty of that evidence, and key judgments.

Results.—: Seven strong recommendations, 4 conditional recommendations, and 5 good practice statements are offered in the guideline update.

Conclusions.—: The updated guideline statements provide direction on the nature of HPV testing in various head and neck specimens (including key updates based on new research on sinonasal squamous cell carcinoma) and expanded guidance on specific scenarios and practice settings. The goal is to improve and standardize, where possible, HPV testing across diverse pathology practice settings and different countries.

头颈癌中人乳头瘤病毒检测:指南更新
上下文。-: 2018年,美国病理学家学会发布了一份基于证据的指南,为头颈癌中高危人乳头瘤病毒和替代标志物检测的检测、应用、解释和报告提供建议。大量的新证据促使我们对人类乳头瘤病毒(HPV)在非口咽解剖部位的数据进行回顾,HPV全球发病率,p16免疫组织化学,细胞学标本中的HPV检测表现,以及p16免疫组织化学作为替代标志物的表现。-:评估自2018年最初指南发布以来发表的研究,并更新头颈癌中HPV检测的循证建议。美国病理学家学院召集了一个专家小组,根据美国国家医学院制定的标准更新指南,以制定值得信赖的临床实践指南。专家小组确定了关键问题,并对文献进行了系统的回顾。采用建议分级评估、发展和评价(GRADE)方法,根据现有证据、证据的确定性和关键判断更新建议。-:在指南更新中提供了7项强烈建议,4项有条件建议和5项良好实践声明。-:更新的指南声明为各种头颈部标本中HPV检测的性质提供了指导(包括基于鼻窦鳞状细胞癌新研究的关键更新),并扩大了具体情况和实践环境的指导。目标是在可能的情况下改进和标准化不同病理实践环境和不同国家的HPV检测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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