Specific types of anxiety regarding radiation therapy in patients with breast cancer: a longitudinal study.

IF 2.9 3区医学 Q1 OBSTETRICS & GYNECOLOGY

Breast Cancer Pub Date : 2025-05-01 Epub Date: 2025-03-23 DOI:10.1007/s12282-025-01690-x

Shi-Jia Wang, Xin Feng, Wei Zhang, Hui Fang, Hao Jing, Yu Tang, Tao Li, Shu-Nan Qi, Yong-Wen Song, Wen-Wen Zhang, Ning-Ning Lu, Yuan Tang, Yue-Ping Liu, Bo Chen, Xin Liu, Ye-Xiong Li, Yi-Rui Zhai, Shu-Lian Wang

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引用次数: 0

Abstract

Purpose: The radiotherapy categorical anxiety scale (RCAS) was designed to evaluate the specific types of radiation therapy (RT)-related anxiety in cancer patients. We translated RCAS into Chinese, evaluated its reliability and validity in breast cancer (BC) patients, and used it to evaluate changes in specific types and levels of RT-related anxiety throughout RT.

Methods: This was a prospective, longitudinal study enrolling 504 Chinese BC patients receiving RT. The patients completed questionnaires assessing the specific types of RT-related anxiety (our Chinese version of RCAS), depression [Patient Health Questionnaire-9 (PHQ-9)], and anxiety [Generalized Anxiety Disorder-7 (GAD-7)] before, during, and after RT. Emotional distress (ED) was defined as a PHQ-9 or GAD-7 score of > 4. Generalized estimating equation was performed to evaluate changes in total and subscale scores on RCAS. Multivariable general linear models were used to explore independent predictors of baseline RCAS scores.

Results: Our Chinese version of RCAS demonstrated high internal consistency (Cronbach's α = 0.89-0.92). Our data demonstrated a Kaiser-Meyer-Olkin measure of 0.946 and P < 0.001 on the Bartlett sphericity test, indicating their suitability for subsequent confirmatory factor analysis (CFA). CFA further demonstrated its adequate convergent and discriminant validity. The levels of anxiety related to RT environment decreased over time, whereas those of anxiety related to RT treatment efficacy remained stable throughout the treatment. Patients demonstrated higher scores on items regarding side effects and treatment efficacy of RT than on other items. ED before RT independently predicted for higher baseline RCAS score.

Conclusions: Our Chinese version of the RCAS can be used to quantitatively evaluate specific types of RT-related anxiety in Chinese BC patients. Clinicians should pay more attention to anxiety regarding the side effects and treatment efficacy of RT reported by their patients, particularly those with baseline ED.

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乳腺癌患者放射治疗相关的特定焦虑类型：一项纵向研究。

目的：设计放射治疗分类焦虑量表（RCAS），评价肿瘤患者放射治疗相关焦虑的具体类型。我们将RCAS翻译成中文，评估了其在乳腺癌（BC）患者中的信度和效度，并用它来评估rt相关焦虑的特定类型和水平在整个rt过程中的变化。这是一项前瞻性、纵向研究，纳入了504名接受rt治疗的中国BC患者。患者在rt之前、rt期间和rt之后完成了评估rt相关焦虑（我们的中文版RCAS）、抑郁（患者健康问卷-9 (PHQ-9)）和焦虑（广泛性焦虑障碍-7 (GAD-7)）特定类型的问卷。采用广义估计方程评价RCAS总分和子量表得分的变化。多变量一般线性模型用于探索基线RCAS评分的独立预测因子。结果：中文版RCAS具有较高的内部一致性（Cronbach’s α = 0.89-0.92）。我们的数据显示Kaiser-Meyer-Olkin测量值为0.946和P。结论：我们的中文版RCAS可用于定量评估中国BC患者rt相关焦虑的特定类型。临床医生应该更多地关注患者报告的关于RT的副作用和治疗效果的焦虑，特别是那些基线ED的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast Cancer ONCOLOGY-OBSTETRICS & GYNECOLOGY

CiteScore

6.70

自引率

2.50%

发文量

105

审稿时长

6-12 weeks

期刊介绍： Breast Cancer, the official journal of the Japanese Breast Cancer Society, publishes articles that contribute to progress in the field, in basic or translational research and also in clinical research, seeking to develop a new focus and new perspectives for all who are concerned with breast cancer. The journal welcomes all original articles describing clinical and epidemiological studies and laboratory investigations regarding breast cancer and related diseases. The journal will consider five types of articles: editorials, review articles, original articles, case reports, and rapid communications. Although editorials and review articles will principally be solicited by the editors, they can also be submitted for peer review, as in the case of original articles. The journal provides the best of up-to-date information on breast cancer, presenting readers with high-impact, original work focusing on pivotal issues.