CX3CR1 Functions as a Biomarker Associated with Pathological Tumor Staging in ‎the Diagnosis and Prognosis of Prostate Cancer.

IF 1.1 4区医学 Q4 IMMUNOLOGY

Iranian Journal of Immunology Pub Date : 2025-03-23 DOI:10.22034/iji.2025.104018.2876

Shiquan Xu, Qing Liu, Jie Wang, Zeyun Zhang, Ying Wang, Li Li, Tao Zhang, Yu Fan

{"title":"CX3CR1 Functions as a Biomarker Associated with Pathological Tumor Staging in ‎the Diagnosis and Prognosis of Prostate Cancer.","authors":"Shiquan Xu, Qing Liu, Jie Wang, Zeyun Zhang, Ying Wang, Li Li, Tao Zhang, Yu Fan","doi":"10.22034/iji.2025.104018.2876","DOIUrl":null,"url":null,"abstract":"Background: Previous research has identified several potential biomarkers associated with pathological ‎tumor (pT) staging in prostate cancer (PCa) patients. Among these biomarkers, CX3CR1 is ‎notable for its connection to the immune microenvironment.‎.Objective‎: To further investigate the significance of CX3CR1 as a key biomarker for predicting pT ‎staging and PCa progression.‎.Methods‎: Prostate cancer tissue samples were analyzed using quantitative reverse transcription ‎polymerase chain reaction (qRT-PCR) and immunohistochemical staining. The diagnostic ‎performance of CX3CR1 was evaluated using receiver operating characteristic (ROC) curves, ‎while Kaplan-Meier survival analysis was conducted to determine overall survival (OS) rates.‎.Results: A significant decrease in CX3CR1 expression was observed in PCa tissues compared to ‎adjacent normal tissues, with the lowest levels detected in pT3 tumors. CX3CR1 expression ‎showed a negative correlation with preoperative prostate-specific antigen (PSA) levels, lymph ‎node staging (N stage), Gleason score, and overall survival (OS). Additionally, CX3CR1 levels ‎were associated with the polarization of infiltrating CD4+ T cells in PCa patients.‎.Conclusion‎: CX3CR1, as a biomarker associated with pT staging, plays a role in predicting PCa prognosis, ‎potentially by modulating the immune microenvironment.‎.","PeriodicalId":54921,"journal":{"name":"Iranian Journal of Immunology","volume":"22 1","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.22034/iji.2025.104018.2876","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Previous research has identified several potential biomarkers associated with pathological ‎tumor (pT) staging in prostate cancer (PCa) patients. Among these biomarkers, CX3CR1 is ‎notable for its connection to the immune microenvironment.‎.

Objective‎: To further investigate the significance of CX3CR1 as a key biomarker for predicting pT ‎staging and PCa progression.‎.

Methods‎: Prostate cancer tissue samples were analyzed using quantitative reverse transcription ‎polymerase chain reaction (qRT-PCR) and immunohistochemical staining. The diagnostic ‎performance of CX3CR1 was evaluated using receiver operating characteristic (ROC) curves, ‎while Kaplan-Meier survival analysis was conducted to determine overall survival (OS) rates.‎.

Results: A significant decrease in CX3CR1 expression was observed in PCa tissues compared to ‎adjacent normal tissues, with the lowest levels detected in pT3 tumors. CX3CR1 expression ‎showed a negative correlation with preoperative prostate-specific antigen (PSA) levels, lymph ‎node staging (N stage), Gleason score, and overall survival (OS). Additionally, CX3CR1 levels ‎were associated with the polarization of infiltrating CD4+ T cells in PCa patients.‎.

Conclusion‎: CX3CR1, as a biomarker associated with pT staging, plays a role in predicting PCa prognosis, ‎potentially by modulating the immune microenvironment.‎.

查看原文本刊更多论文

CX3CR1在前列腺癌诊断和预后中作为与病理肿瘤分期相关的生物标志物

背景：先前的研究已经确定了几种与前列腺癌（PCa）患者病理肿瘤（pT）分期相关的潜在生物标志物。在这些生物标志物中，CX3CR1因其与免疫微环境的联系而值得注意。目的：进一步探讨CX3CR1作为预测pT分期和PCa进展的关键生物标志物的意义。方法：采用定量逆转录聚合酶链反应（qRT-PCR）和免疫组织化学染色对前列腺癌组织标本进行分析。采用受试者工作特征（ROC）曲线评估CX3CR1的诊断效能，同时进行Kaplan-Meier生存分析以确定总生存率（OS）。结果：与邻近正常组织相比，CX3CR1在PCa组织中的表达明显降低，在pT3肿瘤中表达水平最低。CX3CR1表达与术前前列腺特异性抗原（PSA）水平、淋巴结分期（N期）、Gleason评分和总生存期（OS）呈负相关。此外，CX3CR1水平与PCa患者浸润性CD4+ T细胞的极化有关。结论：CX3CR1作为一种与前列腺癌分期相关的生物标志物，可能通过调节免疫微环境来预测前列腺癌的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Iranian Journal of Immunology Medicine-Immunology and Allergy

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： The Iranian Journal of Immunology (I.J.I) is an internationally disseminated peer-reviewed publication and publishes a broad range of experimental and theoretical studies concerned with all aspects of immunology.