CX3CR1 Functions as a Biomarker Associated with Pathological Tumor Staging in ‎the Diagnosis and Prognosis of Prostate Cancer.

IF 1.1 4区医学 Q4 IMMUNOLOGY

Iranian Journal of Immunology Pub Date : 2025-03-23 DOI:10.22034/iji.2025.104018.2876

Shiquan Xu, Qing Liu, Jie Wang, Zeyun Zhang, Ying Wang, Li Li, Tao Zhang, Yu Fan

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引用次数: 0

Abstract

Background: Previous research has identified several potential biomarkers associated with pathological ‎tumor (pT) staging in prostate cancer (PCa) patients. Among these biomarkers, CX3CR1 is ‎notable for its connection to the immune microenvironment.‎.

Objective‎: To further investigate the significance of CX3CR1 as a key biomarker for predicting pT ‎staging and PCa progression.‎.

Methods‎: Prostate cancer tissue samples were analyzed using quantitative reverse transcription ‎polymerase chain reaction (qRT-PCR) and immunohistochemical staining. The diagnostic ‎performance of CX3CR1 was evaluated using receiver operating characteristic (ROC) curves, ‎while Kaplan-Meier survival analysis was conducted to determine overall survival (OS) rates.‎.

Results: A significant decrease in CX3CR1 expression was observed in PCa tissues compared to ‎adjacent normal tissues, with the lowest levels detected in pT3 tumors. CX3CR1 expression ‎showed a negative correlation with preoperative prostate-specific antigen (PSA) levels, lymph ‎node staging (N stage), Gleason score, and overall survival (OS). Additionally, CX3CR1 levels ‎were associated with the polarization of infiltrating CD4+ T cells in PCa patients.‎.

Conclusion‎: CX3CR1, as a biomarker associated with pT staging, plays a role in predicting PCa prognosis, ‎potentially by modulating the immune microenvironment.‎.

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来源期刊

Iranian Journal of Immunology Medicine-Immunology and Allergy

CiteScore

1.60

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： The Iranian Journal of Immunology (I.J.I) is an internationally disseminated peer-reviewed publication and publishes a broad range of experimental and theoretical studies concerned with all aspects of immunology.