Development of a PET-CT Based Radiomics Model for Preoperative Prediction of the Novel IASLC Grading and Prognosis in Patients with Clinical Stage I Pure Solid Invasive Lung Adenocarcinoma.
IF 3.8 2区 医学Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
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引用次数: 0
Abstract
Rationale and objectives: To develop and validate a fluorine-18-fludeoxyglucose (18F-FDG) PET/CT-based radiomics nomogram for preoperative prediction of the International Association for the Study of Lung Cancer (IASLC) grading and recurrence-free survival (RFS) in patients with clinical stage I pure-solid invasive lung adenocarcinoma (LADC). MATERIALS AND METHODS: 418 patients with clinical stage I pure-solid invasive LADC who underwent preoperative 18F-FDG PET/CT examination were retrospectively enrolled. All patients were separated into the low-grade group (grade I and II; n=315) and the high-grade group (grade III; n=103) according to the IASLC grading system, and the cohort was randomly divided into a training set (n=292) and a testing set (n=126) at a ratio of 7:3. Radiomics features were extracted from CT and PET images in regions of the entire tumor. Multivariate analysis identified the independent predictors for IASLC grading and RFS. The Radscore, along with clinical and radiological features were combined to establish a predictive nomogram.
Results: The ultimate Radiomics model, achieving AUCs of 0.838 and 0.768 in the training and testing sets. The multivariate logistic regression showed that higher maximum standard uptake value (SUVmax), cavity presence are the independent risk factors for IASLC grading. The integrated nomogram showed superior prediction performance than CT model (p=0.001) and PET model (p=0.028) in the training set. Furthermore, both pathological grade and preoperatively predictive IASLC grade derived by nomogram significantly stratified patients for RFS, with 5-year survival rates showing marked differences between low-grade and high-grade LADC (p<0.001).
Conclusion: The preoperative PET/CT-based radiomics nomogram represents a potential biomarker for predicting IASLC grade and RFS in patients with clinical stage I pure-solid invasive LADC.
期刊介绍：
Academic Radiology publishes original reports of clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, image-guided interventions and related techniques. It also includes brief technical reports describing original observations, techniques, and instrumental developments; state-of-the-art reports on clinical issues, new technology and other topics of current medical importance; meta-analyses; scientific studies and opinions on radiologic education; and letters to the Editor.
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