In Vitro Ovine Cam Impingement Model and Its Effect on Acetabular Cartilage.

IF 2.4 3区 医学 Q2 ORTHOPEDICS
Orthopaedic Journal of Sports Medicine Pub Date : 2025-03-21 eCollection Date: 2025-03-01 DOI:10.1177/23259671251322757
Onur Hapa, Selahaddin Aydemir, Fatma Bahar Sunay, Ahmet Emrah Acan, Pakize Nur Akkaya, Mustafa Celtik, Resit Bugra Husemoglu, Mehmet Salin
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引用次数: 0

Abstract

Background: Femoroacetabular impingement syndrome is a condition where abnormal contact occurs between the femoral head and the acetabulum, leading to chondral damage and hip osteoarthritis. To better understand and treat femoroacetabular impingement syndrome, it is crucial to establish in vitro models that mimic the condition and assess potential interventions.

Purpose: To establish an in vitro ovine cam impingement model and assess the effectiveness of cam excision in reducing the incidence of type 3 acetabular labrum articular disruption (ALAD) (chondral flap) lesions.

Study design: Controlled laboratory study.

Methods: Utilizing an ovine in vitro cam impingement model, 40 hips were subjected to testing across 5 groups (n = 8 per group): group 1 (control group), 750 N for 200 cycles; group 2 (cycle decrease), 750 N for 100 cycles; group 3 (load decrease), 500 N for 200 cycles; group 4 (cam excision), cam excision followed by 750 N for 200 cycles; and group 5 (halfway cam excision), 750 N for 100 cycles followed by cam excision under an additional 750 N for 100 cycles loading. Each specimen was subsequently assessed for chondral damage according to the ALAD classification, both macroscopically and microscopically.

Results: The control group (group 1) demonstrated the highest ALAD scores (2.7 ± 0.4, 2.8 ± 0.3) compared with other groups, whereas the cam excision group (group 4) exhibited lower scores (0.5 ± 0.5, 0.7 ± 0.4) than both the cycle decrease group (group 2) (1.6 ± 0.5, 1.6 ± 0.5) and the halfway cam excision group (group 5) (1.8 ± 0.6, 2 ± 0.5) (P < .05) in both macroscopic and microscopic gradings (P < .05). The load decrease group (group 3) (1 ± 0.5) also displayed lower scores compared with group 5 (2 ± 0.5) at histological grading (P < .05).

Conclusion: An in vitro sheep model was established that reliably induces mechanical chondrolabral damage in the hip joint. The findings show that reducing the load results in less chondrolabral damage compared with reducing the number of cycles. Furthermore, this model emphasizes the protective effect of cam excision in the management of chondral flap lesions (ALAD type 3).

绵羊凸轮撞击体外模型及其对髋臼软骨的影响。
背景:股髋臼撞击综合征是股骨头与髋臼之间发生异常接触,导致软骨损伤和髋关节骨关节炎的一种疾病。为了更好地了解和治疗股髋臼撞击综合征,建立模拟该疾病的体外模型并评估潜在的干预措施至关重要。目的:建立离体绵羊凸轮撞击模型,评估凸轮切除对降低3型髋臼唇关节破裂(ALAD)(软骨瓣)病变发生率的效果。研究设计:实验室对照研究。方法:采用绵羊体外凸轮撞击模型,将40只髋关节分为5组(每组8只)进行试验:1组(对照组),750 n, 200周期;组2(周期递减),750 N, 100个周期;组3(减载),500 N, 200次循环;第4组(凸轮切除),凸轮切除后给予750 N, 200个周期;第5组(半凸轮切除),750 N, 100次循环,然后在额外750 N, 100次循环的载荷下凸轮切除。随后根据ALAD分类对每个标本进行宏观和微观的软骨损伤评估。结果:对照组(1组)ALAD评分最高(2.7±0.4,2.8±0.3),凸轮切除组(4组)宏观和微观评分均低于周期减少组(2组)(1.6±0.5,1.6±0.5)和半凸轮切除组(5组)(1.8±0.6,2±0.5)(P < 0.05) (P < 0.05)。减负组(3组)的组织学评分(1±0.5)也低于减负组(2±0.5)(P < 0.05)。结论:建立了一种可靠的绵羊髋关节机械关节损伤体外模型。研究结果表明,与减少循环次数相比,减少负荷导致较少的软骨唇损伤。此外,该模型强调了cam切除在处理软骨瓣病变(ALAD 3型)中的保护作用。
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来源期刊
Orthopaedic Journal of Sports Medicine
Orthopaedic Journal of Sports Medicine Medicine-Orthopedics and Sports Medicine
CiteScore
4.30
自引率
7.70%
发文量
876
审稿时长
12 weeks
期刊介绍: The Orthopaedic Journal of Sports Medicine (OJSM), developed by the American Orthopaedic Society for Sports Medicine (AOSSM), is a global, peer-reviewed, open access journal that combines the interests of researchers and clinical practitioners across orthopaedic sports medicine, arthroscopy, and knee arthroplasty. Topics include original research in the areas of: -Orthopaedic Sports Medicine, including surgical and nonsurgical treatment of orthopaedic sports injuries -Arthroscopic Surgery (Shoulder/Elbow/Wrist/Hip/Knee/Ankle/Foot) -Relevant translational research -Sports traumatology/epidemiology -Knee and shoulder arthroplasty The OJSM also publishes relevant systematic reviews and meta-analyses. This journal is a member of the Committee on Publication Ethics (COPE).
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