Trends in Mortality Related to Atrial Fibrillation and Dementia in Older Adults in the United States: A 2000-2020 Analysis.

IF 2.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Electrophysiology Pub Date : 2025-03-24 DOI:10.1111/jce.16644

Muhammad U Sohail, Ruqiat M Batool, Muhammad Saad, Saad A Waqas, Muhammed A Noushad, Muhammad O Sohail, Matthew Bates, Raheel Ahmed, David Ripley

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引用次数: 0

Abstract

Background: Atrial fibrillation (AF) and dementia are increasingly prevalent in aging US populations. Their association raises public health concerns, emphasizing the need to understand mortality trends in older adults. This study examines AF and dementia-related mortality trends from 2000 to 2020.

Methods: Using the CDC WONDER Multiple Cause of Death database, we analyzed death certificates for individuals aged 65 and older, reporting age-adjusted mortality rates (AAMRs) per 100 000 persons. Trends were assessed through annual percent change (APC) analysis via Joinpoint regression, with stratifications by sex, race/ethnicity, urbanization, and Census regions.

Results: A total of 400 103 AF and dementia-related deaths were recorded between 2000 and 2020. The AAMR increased markedly from 25.4 in 2000 to 70.4 in 2020. The overall AAMR showed a steady increase from 2000 to 2018 (APC: +4.2%; 95% CI: 2.5-5.5), with a sharper rise from 2018 to 2020 (APC: +9.5%; 95% CI: 4.5-12.2; p < 0.001). Mortality rates were comparable between men (AAMR: 44.4) and women (AAMR: 43.9). NH White individuals exhibited the highest AAMR (47.0), followed by NH Black (26.6), Hispanic (23.1), and NH Asian/Pacific Islander (18.0) populations. Nonmetropolitan areas had higher AAMRs (48.1) compared to metropolitan areas (43.5). Regionally, the Western US recorded the highest AAMR at 48.2, while state-level disparities showed a nearly threefold difference between the top 90th and bottom 10th percentiles.

Conclusion: Rising AF and dementia-related mortality rates among older adults highlight a need for targeted screening and intervention, particularly for high-risk demographics and underserved regions.

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美国老年人心房颤动和痴呆相关死亡率趋势：2000-2020年分析

背景：心房颤动（房颤）和痴呆症在美国老龄人口中越来越普遍。它们之间的关联引发了公共卫生问题，强调了了解老年人死亡率趋势的必要性。本研究探讨了 2000 年至 2020 年心房颤动和痴呆症相关的死亡率趋势：我们使用美国疾病预防控制中心 WONDER 多死因数据库，分析了 65 岁及以上人群的死亡证明，报告了每 10 万人的年龄调整死亡率 (AAMR)。通过Joinpoint回归进行年度百分比变化（APC）分析，并按性别、种族/人种、城市化和人口普查地区进行分层，从而对趋势进行评估：2000 年至 2020 年间，共记录了 400 103 例房颤和痴呆相关死亡。急性心房颤动死亡率从 2000 年的 25.4 显著上升至 2020 年的 70.4。从2000年到2018年，总体AAMR呈稳步上升趋势（APC：+4.2%；95% CI：2.5-5.5），2018年到2020年上升幅度更大（APC：+9.5%；95% CI：4.5-12.2；P 结论：老年人心房颤动和痴呆相关死亡率的上升凸显了有针对性筛查和干预的必要性，尤其是针对高风险人群和服务不足地区。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiovascular Electrophysiology 医学-心血管系统

CiteScore

5.20

自引率

14.80%

发文量

433

审稿时长

3-6 weeks

期刊介绍： Journal of Cardiovascular Electrophysiology (JCE) keeps its readership well informed of the latest developments in the study and management of arrhythmic disorders. Edited by Bradley P. Knight, M.D., and a distinguished international editorial board, JCE is the leading journal devoted to the study of the electrophysiology of the heart.