Prostate cancer detection with transrectal in-bore MRI biopsies: impact of prostate volume and lesion features.

IF 4.1 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Insights into Imaging Pub Date : 2025-03-23 DOI:10.1186/s13244-025-01942-6

Alexander Schaudinn, Harald Busse, Constantin Ehrengut, Nicolas Linder, Jonna Ludwig, Toni Franz, Lars-Christian Horn, Jens-Uwe Stolzenburg, Timm Denecke

{"title":"Prostate cancer detection with transrectal in-bore MRI biopsies: impact of prostate volume and lesion features.","authors":"Alexander Schaudinn, Harald Busse, Constantin Ehrengut, Nicolas Linder, Jonna Ludwig, Toni Franz, Lars-Christian Horn, Jens-Uwe Stolzenburg, Timm Denecke","doi":"10.1186/s13244-025-01942-6","DOIUrl":null,"url":null,"abstract":"Objectives: To systematically analyze the diagnostic outcome of transrectal in-bore MRI-guided biopsies as a function of prostate volume and lesion features.Methods: This single-center study retrospectively included 184 consecutive patients with transrectal in-bore MRI biopsies and histological analysis after multiparametric MRI diagnostics of at least one PI-RADS ≥ 3 lesion. Diagnostic and biopsy MRI data were analyzed for a number of patient and imaging features, specifically prostate volume, lesion size, lesion location (longitudinal, sagittal and segmental) and lesion depth. Features were then compared for statistically significant differences in the cancer detection rate (CDR) of clinically significant (cs-PCa) and any prostate cancer (any-PCa) using categorical and continuous variables.Results: A total of 201 lesions were biopsied detecting cs-PCa in 26% and any-PCa in 68%, respectively. In subgroup analyses of all features, the CDR of cs-PCa differed significantly between ranges of lesion size only (p < 0.001, largest for large lesions). In multivariable analysis, however, only PI-RADS score and PSA showed a significant association with a higher risk of cs-PCa.Conclusions: The cancer detection rates of transrectal in-bore MRI-guided biopsies did not vary significantly for prostate volume, lesion size or lesion location. This suggests that the diagnostic performance of such an approach is not necessarily compromised for challenging biopsy settings like large glands, small lesions or eccentric locations. A translation of these findings to other cohorts might be limited by the low detection rate for clinically significant cancer.Critical relevance statement: This systematic analysis indicates that the diagnostic performance of transrectal in-bore biopsies might not be substantially impaired by patient-specific factors like prostate volume, lesion size, and lesion location, making it a viable option for challenging biopsy cases as well.Key points: The impact of prostate and lesion features on in-bore MRI biopsy performance is controversial. Neither prostate volume, lesion size, nor location showed significant impact on cancer detection. In-bore biopsy does not seem to be limited by challenging sampling geometries.","PeriodicalId":13639,"journal":{"name":"Insights into Imaging","volume":"16 1","pages":"69"},"PeriodicalIF":4.1000,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930903/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Insights into Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13244-025-01942-6","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: To systematically analyze the diagnostic outcome of transrectal in-bore MRI-guided biopsies as a function of prostate volume and lesion features.

Methods: This single-center study retrospectively included 184 consecutive patients with transrectal in-bore MRI biopsies and histological analysis after multiparametric MRI diagnostics of at least one PI-RADS ≥ 3 lesion. Diagnostic and biopsy MRI data were analyzed for a number of patient and imaging features, specifically prostate volume, lesion size, lesion location (longitudinal, sagittal and segmental) and lesion depth. Features were then compared for statistically significant differences in the cancer detection rate (CDR) of clinically significant (cs-PCa) and any prostate cancer (any-PCa) using categorical and continuous variables.

Results: A total of 201 lesions were biopsied detecting cs-PCa in 26% and any-PCa in 68%, respectively. In subgroup analyses of all features, the CDR of cs-PCa differed significantly between ranges of lesion size only (p < 0.001, largest for large lesions). In multivariable analysis, however, only PI-RADS score and PSA showed a significant association with a higher risk of cs-PCa.

Conclusions: The cancer detection rates of transrectal in-bore MRI-guided biopsies did not vary significantly for prostate volume, lesion size or lesion location. This suggests that the diagnostic performance of such an approach is not necessarily compromised for challenging biopsy settings like large glands, small lesions or eccentric locations. A translation of these findings to other cohorts might be limited by the low detection rate for clinically significant cancer.

Critical relevance statement: This systematic analysis indicates that the diagnostic performance of transrectal in-bore biopsies might not be substantially impaired by patient-specific factors like prostate volume, lesion size, and lesion location, making it a viable option for challenging biopsy cases as well.

Key points: The impact of prostate and lesion features on in-bore MRI biopsy performance is controversial. Neither prostate volume, lesion size, nor location showed significant impact on cancer detection. In-bore biopsy does not seem to be limited by challenging sampling geometries.

查看原文本刊更多论文

经直肠腔内MRI活检检测前列腺癌：前列腺体积和病变特征的影响。

目的：系统分析经直肠mri引导下活检的诊断结果与前列腺体积和病变特征的关系。方法：本单中心研究回顾性纳入184例连续患者，在多参数MRI诊断至少一个PI-RADS≥3的病变后，进行经直肠腔内MRI活检和组织学分析。诊断和活检MRI数据分析了许多患者和影像学特征，特别是前列腺体积，病变大小，病变位置（纵向，矢状和节段性）和病变深度。然后使用分类变量和连续变量比较临床显著性前列腺癌（cs-PCa）和任何前列腺癌（any- pca）的癌症检出率（CDR）的统计学差异。结果：201例病变活检发现cs-PCa占26%，任何- pca占68%。在所有特征的亚组分析中，cs-PCa的CDR仅在病变大小范围内存在显著差异(p)。结论：经直肠mri引导下穿刺活检的癌检出率在前列腺体积、病变大小和病变位置上无显著差异。这表明，这种方法的诊断性能并不一定会损害具有挑战性的活检设置，如大腺体，小病变或偏心位置。将这些发现转化到其他队列可能受到临床重要癌症的低检出率的限制。关键相关性声明：该系统分析表明，经直肠穿刺活检的诊断性能可能不会受到患者特异性因素（如前列腺体积、病变大小和病变位置）的严重影响，这也使其成为具有挑战性的活检病例的可行选择。重点：前列腺和病变特征对穿刺MRI活检表现的影响是有争议的。前列腺体积、病变大小和位置对癌症检测均无显著影响。井内活检似乎不受采样几何形状的限制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Insights into Imaging Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

7.30

自引率

4.30%

发文量

182

审稿时长

13 weeks

期刊介绍： Insights into Imaging (I³) is a peer-reviewed open access journal published under the brand SpringerOpen. All content published in the journal is freely available online to anyone, anywhere! I³ continuously updates scientific knowledge and progress in best-practice standards in radiology through the publication of original articles and state-of-the-art reviews and opinions, along with recommendations and statements from the leading radiological societies in Europe. Founded by the European Society of Radiology (ESR), I³ creates a platform for educational material, guidelines and recommendations, and a forum for topics of controversy. A balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes I³ an indispensable source for current information in this field. I³ is owned by the ESR, however authors retain copyright to their article according to the Creative Commons Attribution License (see Copyright and License Agreement). All articles can be read, redistributed and reused for free, as long as the author of the original work is cited properly. The open access fees (article-processing charges) for this journal are kindly sponsored by ESR for all Members. The journal went open access in 2012, which means that all articles published since then are freely available online.