Myocardial late enhancement using dual-source CT: intraindividual comparison of single-energy shuttle and dual-energy acquisition.

IF 4.1 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Insights into Imaging Pub Date : 2025-03-22 DOI:10.1186/s13244-025-01944-4

Takanori Kokawa, Kakuya Kitagawa, Satoshi Nakamura, Masafumi Takafuji, Takashi Oya, Hajime Sakuma

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引用次数: 0

Abstract

Objectives: Myocardial computed tomography late enhancement (CT-LE) is a valuable modality used for the assessment of myocardial infarction and fibrosis and is effective in detecting latent cardiac amyloidosis. However, the optimal acquisition mode for CT-LE remains unknown. Here, we compared single-energy shuttle mode and DE mode for improving the quality of CT-LE imaging using dual-source CT.

Methods: Fifteen patients with suspected or known ischemic heart disease underwent CT-LE imaging 5 min after coronary CT in both shuttle and dual-energy (DE) modes. In DE mode, virtual monoenergetic images at various keVs were reconstructed, and extracellular volume (ECV) was quantified using iodine-specific images. For shuttle mode, ECV was assessed by subtracting the volume from pre-contrast images from CT-LE after non-rigid registration.

Results: In DE mode, signal-noise-to-ratio was the highest at 70 keV, but it was still lower than that in shuttle mode (p < 0.001). Contrast-noise-to-ratio was the highest on DE mode at 40 keV and was comparable with that in shuttle mode (p = 0.51). Interobserver agreement for infarct detection was higher in shuttle mode (kappa = 0.981) compared to DE mode (kappa = 0.808). Global ECV was comparable between shuttle and DE modes (p = 0.96). However, the coefficient of variation of segmental ECV was significantly lower in shuttle mode (p < 0.001).

Conclusion: Shuttle mode CT-LE demonstrates superior image quality, better agreement in infarct detection, and ECV consistency in comparison to DE mode, suggesting its potential as the preferred approach for CT-LE imaging using dual-source CT despite limited z-axis coverage of 10.5 cm.

Clinical relevance statement: CT late enhancement imaging in shuttle mode provides superior image quality and consistent extracellular volume measurements compared to dual-energy mode, highlighting its potential as the preferred acquisition method for CT late enhancement imaging in dual-source CT.

Key points: Shuttle mode and dual-energy acquisition are compared for optimal myocardial CT-late enhancement (CT-LE) imaging. Shuttle mode can provide better image quality and more consistent extracellular volume measurements. Despite limited coverage, shuttle mode may be preferred for myocardial CT-LE imaging.

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双源CT心肌晚期增强：单能量穿梭与双能量获取的个体比较。

目的：心肌计算机断层扫描晚期增强（CT-LE）是评估心肌梗死和纤维化的一种有价值的方式，可以有效地检测潜在的心肌淀粉样变性。然而，CT-LE的最佳获取方式尚不清楚。在这里，我们比较了单能量穿梭模式和DE模式，以提高双源CT CT- le成像质量。方法：15例疑似或已知缺血性心脏病患者在冠状动脉CT扫描后5分钟行穿梭和双能（DE）模式CT- le成像。在DE模式下，重建不同keVs的虚拟单能图像，并使用碘特异性图像量化细胞外体积（ECV）。对于穿梭模式，在非刚性配准后，通过从CT-LE的对比度前图像中减去体积来评估ECV。结果：在DE模式下，信噪比在70 keV时最高，但仍低于穿梭模式(p)。结论：与DE模式相比，穿梭模式CT- le图像质量更好，梗死检测一致性更好，ECV一致性更好，尽管z轴覆盖范围有限，但仍有潜力成为双源CT CT- le成像的首选方法。临床相关性声明：与双能量模式相比，穿梭模式的CT晚期增强成像提供了更好的图像质量和一致的细胞外体积测量，突出了其作为双源CT晚期增强成像首选采集方法的潜力。重点：比较穿梭模式和双能量采集的最佳心肌ct -晚期增强（CT-LE）成像。穿梭模式可以提供更好的图像质量和更一致的细胞外体积测量。尽管覆盖范围有限，但穿梭模式可能是心肌CT-LE成像的首选。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Insights into Imaging Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

7.30

自引率

4.30%

发文量

182

审稿时长

13 weeks

期刊介绍： Insights into Imaging (I³) is a peer-reviewed open access journal published under the brand SpringerOpen. All content published in the journal is freely available online to anyone, anywhere! I³ continuously updates scientific knowledge and progress in best-practice standards in radiology through the publication of original articles and state-of-the-art reviews and opinions, along with recommendations and statements from the leading radiological societies in Europe. Founded by the European Society of Radiology (ESR), I³ creates a platform for educational material, guidelines and recommendations, and a forum for topics of controversy. A balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes I³ an indispensable source for current information in this field. I³ is owned by the ESR, however authors retain copyright to their article according to the Creative Commons Attribution License (see Copyright and License Agreement). All articles can be read, redistributed and reused for free, as long as the author of the original work is cited properly. The open access fees (article-processing charges) for this journal are kindly sponsored by ESR for all Members. The journal went open access in 2012, which means that all articles published since then are freely available online.