Construction and validation of a risk stratification model based on Lung-RADS® v2022 and CT features for predicting the invasive pure ground-glass pulmonary nodules in China.

IF 4.1 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Qingcheng Meng, Tong Liu, Hui Peng, Pengrui Gao, Wenda Chen, Mengjia Fang, Wentao Liu, Hong Ge, Renzhi Zhang, Xuejun Chen
{"title":"Construction and validation of a risk stratification model based on Lung-RADS<sup>®</sup> v2022 and CT features for predicting the invasive pure ground-glass pulmonary nodules in China.","authors":"Qingcheng Meng, Tong Liu, Hui Peng, Pengrui Gao, Wenda Chen, Mengjia Fang, Wentao Liu, Hong Ge, Renzhi Zhang, Xuejun Chen","doi":"10.1186/s13244-025-01937-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>A novel risk stratification model based on Lung-RADS<sup>®</sup> v2022 and CT features was constructed and validated for predicting invasive pure ground-glass nodules (pGGNs) in China.</p><p><strong>Methods: </strong>Five hundred and twenty-six patients with 572 pulmonary GGNs were prospectively enrolled and divided into training (n = 169) and validation (n = 403) sets. Utilising the Lung-RADS<sup>®</sup> v2022 framework and the types of GGN-vessel relationships (GVR), a complementary Lung-RADS<sup>®</sup> v2022 was established, and the pGGNs were reclassified from categories 2, 3 and 4x of Lung-RADS<sup>®</sup> v2022 into 2, 3, 4a, 4b, and 4x of cLung-RADS<sup>®</sup> v2022. The cutoff value of invasive pGGNs was defined as the cLung-RADS<sup>®</sup> v2022 4a-4x. Evaluation metrics like recall rate, precision, F1 score, accuracy, Matthews correlation coefficient (MCC), and the area under the receiver operating characteristic curve (AUC) were employed to assess the utility of the cLung-RADS<sup>®</sup> v2022.</p><p><strong>Results: </strong>In the training set, compared with the Lung-RADS 1.0, the AUC of Lung-RADS<sup>®</sup> v2022 were decreased from 0.543 to 0.511 (p-value = 0.002), and compared to Lung-RADS 1.0 and Lung-RADS<sup>®</sup> v2022, the cLung-RADS<sup>®</sup> v2022 model exhibited the highest recall rate (94.9% vs 6.5%, 2.2%), MCC value (60.2% vs 5.4%, 6.3%), F1 score (92.5% vs 12.1%, 4.3%), accuracy (87.6% vs 23.1%, 19.5%), and AUC (0.718 vs 0.543, 0.511; p-value = 0.014, 0.0016) in diagnosing the invasiveness of pGGNs, and the similar performance was observed in the validation set.</p><p><strong>Conclusion: </strong>The cLung-RADS<sup>®</sup> v2022 can effectively predict the invasiveness of pGGNs in real-world scenarios.</p><p><strong>Critical relevance statement: </strong>A complementary Lung-RADS<sup>®</sup> v2022 based on the Lung-RADS<sup>®</sup> v2022 and CT features can effectively predict the invasiveness of pulmonary pure ground-glass nodules and is applicable in clinical practice.</p><p><strong>Trial registration: </strong>Establishment and application of a multi-scale low-dose CT Lung cancer screening model based on modified lung-RADS1.1 and deep learning technology, 2022-KY-0137. Registered 24 January 2022. https://www.medicalresearch.org.cn/search/research/researchView?id=a97e67d8-1ee6-40fb-aab1-e6238dbd8f29 .</p><p><strong>Key points: </strong>Lung-RADS<sup>®</sup> v2022 delayed lung cancer diagnosis for nodules appearing as pGGNs. Lung-RADS<sup>®</sup> v2022 showed lower accuracy and AUC than Lung-RADS 1.0. cLung-RADS<sup>®</sup> v2022 model effectively predicts the invasiveness of pulmonary pGGNs.</p>","PeriodicalId":13639,"journal":{"name":"Insights into Imaging","volume":"16 1","pages":"68"},"PeriodicalIF":4.1000,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930897/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Insights into Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13244-025-01937-3","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0

Abstract

Objectives: A novel risk stratification model based on Lung-RADS® v2022 and CT features was constructed and validated for predicting invasive pure ground-glass nodules (pGGNs) in China.

Methods: Five hundred and twenty-six patients with 572 pulmonary GGNs were prospectively enrolled and divided into training (n = 169) and validation (n = 403) sets. Utilising the Lung-RADS® v2022 framework and the types of GGN-vessel relationships (GVR), a complementary Lung-RADS® v2022 was established, and the pGGNs were reclassified from categories 2, 3 and 4x of Lung-RADS® v2022 into 2, 3, 4a, 4b, and 4x of cLung-RADS® v2022. The cutoff value of invasive pGGNs was defined as the cLung-RADS® v2022 4a-4x. Evaluation metrics like recall rate, precision, F1 score, accuracy, Matthews correlation coefficient (MCC), and the area under the receiver operating characteristic curve (AUC) were employed to assess the utility of the cLung-RADS® v2022.

Results: In the training set, compared with the Lung-RADS 1.0, the AUC of Lung-RADS® v2022 were decreased from 0.543 to 0.511 (p-value = 0.002), and compared to Lung-RADS 1.0 and Lung-RADS® v2022, the cLung-RADS® v2022 model exhibited the highest recall rate (94.9% vs 6.5%, 2.2%), MCC value (60.2% vs 5.4%, 6.3%), F1 score (92.5% vs 12.1%, 4.3%), accuracy (87.6% vs 23.1%, 19.5%), and AUC (0.718 vs 0.543, 0.511; p-value = 0.014, 0.0016) in diagnosing the invasiveness of pGGNs, and the similar performance was observed in the validation set.

Conclusion: The cLung-RADS® v2022 can effectively predict the invasiveness of pGGNs in real-world scenarios.

Critical relevance statement: A complementary Lung-RADS® v2022 based on the Lung-RADS® v2022 and CT features can effectively predict the invasiveness of pulmonary pure ground-glass nodules and is applicable in clinical practice.

Trial registration: Establishment and application of a multi-scale low-dose CT Lung cancer screening model based on modified lung-RADS1.1 and deep learning technology, 2022-KY-0137. Registered 24 January 2022. https://www.medicalresearch.org.cn/search/research/researchView?id=a97e67d8-1ee6-40fb-aab1-e6238dbd8f29 .

Key points: Lung-RADS® v2022 delayed lung cancer diagnosis for nodules appearing as pGGNs. Lung-RADS® v2022 showed lower accuracy and AUC than Lung-RADS 1.0. cLung-RADS® v2022 model effectively predicts the invasiveness of pulmonary pGGNs.

基于Lung-RADS®v2022和CT特征的中国纯毛玻璃肺浸润性结节风险分层模型的构建与验证
目的:建立一种基于Lung-RADS®v2022和CT特征的新型风险分层模型,并对其进行验证,用于预测侵袭性纯磨玻璃结节(pggn)。方法:前瞻性纳入526例572例肺ggn患者,分为训练组(n = 169)和验证组(n = 403)。利用Lung-RADS®v2022框架和ggn -血管关系类型(GVR),建立了互补的Lung-RADS®v2022,并将pggn从Lung-RADS®v2022的2、3和4x类重新分类为Lung-RADS®v2022的2、3、4a、4b和4x类。浸润性pggn的临界值定义为lung - rads®v2022 4a-4x。评估指标包括召回率、准确率、F1评分、准确率、马修斯相关系数(MCC)和受试者工作特征曲线下面积(AUC)来评估cllung - rads®v2022的实用性。结果:在训练集中,与Lung-RADS 1.0相比,Lung-RADS®v2022的AUC从0.543降低到0.511 (p值= 0.002),并且与Lung-RADS®v2022和Lung-RADS®v2022相比,Lung-RADS®v2022模型具有最高的召回率(94.9% vs 6.5%, 2.2%)、MCC值(60.2% vs 5.4%, 6.3%)、F1评分(92.5% vs 12.1%, 4.3%)、准确率(87.6% vs 23.1%, 19.5%)和AUC (0.718 vs 0.543, 0.511;p值= 0.014,0.0016)在诊断pggn的侵袭性方面,在验证集中也观察到类似的性能。结论:cLung-RADS®v2022可有效预测pggn的侵袭性。关键相关性声明:基于Lung-RADS®v2022和CT特征的互补Lung-RADS®v2022可有效预测肺部纯磨玻璃结节的侵袭性,具有临床应用价值。试验注册:基于改进Lung - rads1.1和深度学习技术的多尺度低剂量CT肺癌筛查模型的建立与应用,编号2022- key -0137。注册于2022年1月24日。https://www.medicalresearch.org.cn/search/research/researchView?id=a97e67d8-1ee6-40fb-aab1-e6238dbd8f29 .重点:lung - rads®v2022延迟肺癌诊断结节表现为pggn。Lung-RADS®v2022的准确性和AUC低于Lung-RADS 1.0。cLung-RADS®v2022模型可有效预测肺部pggn的侵袭性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Insights into Imaging
Insights into Imaging Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
7.30
自引率
4.30%
发文量
182
审稿时长
13 weeks
期刊介绍: Insights into Imaging (I³) is a peer-reviewed open access journal published under the brand SpringerOpen. All content published in the journal is freely available online to anyone, anywhere! I³ continuously updates scientific knowledge and progress in best-practice standards in radiology through the publication of original articles and state-of-the-art reviews and opinions, along with recommendations and statements from the leading radiological societies in Europe. Founded by the European Society of Radiology (ESR), I³ creates a platform for educational material, guidelines and recommendations, and a forum for topics of controversy. A balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes I³ an indispensable source for current information in this field. I³ is owned by the ESR, however authors retain copyright to their article according to the Creative Commons Attribution License (see Copyright and License Agreement). All articles can be read, redistributed and reused for free, as long as the author of the original work is cited properly. The open access fees (article-processing charges) for this journal are kindly sponsored by ESR for all Members. The journal went open access in 2012, which means that all articles published since then are freely available online.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信