"Dr. Jekyll and Mr. Hyde": AT2 Cells in Lung Regeneration and Tumor Development.

IF 12.5 1区医学 Q1 ONCOLOGY

Cancer research Pub Date : 2025-05-15 DOI:10.1158/0008-5472.CAN-25-1177

Xinyuan Tong, Gen Lin, Hongbin Ji

引用次数: 0

Abstract

Alveolar type II cells, the primary stem cell population in the distal lung epithelium, are known to be the most common cell of origin for lung adenocarcinoma. A recent study published in Cell Stem Cell reveals that KRASG12D-mutant alveolar type II cells hijack lung regeneration programs to initiate lung adenocarcinoma, resembling "Dr. Jekyll and Mr. Hyde" in which their "Jekyll" side promotes tissue repair, whereas their "Hyde" side drives tumorigenesis. Sustained NF-κB activation drives lineage infidelity, enabling these mutant cells to bypass normal differentiation, remodel the surrounding microenvironment, and, ultimately, promote tumorigenesis.

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“化身博士”：AT2细胞在肺再生和肿瘤发展中的作用。

肺泡II型（AT2）细胞是远端肺上皮的原代干细胞群，是肺腺癌（LUAD）最常见的起源细胞。最近发表在《细胞干细胞》杂志上的一项研究表明，KRASG12D突变的AT2细胞劫持肺再生程序，引发肺腺癌，类似于“化身博士和化身先生”，其中“化身博士”的一面促进组织修复，而“化身先生”的一面推动肿瘤发生。持续的NF-κB激活驱动谱系不忠，使这些突变细胞绕过正常分化，重塑周围微环境，最终促进肿瘤发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer research 医学-肿瘤学

CiteScore

16.10

自引率

0.90%

发文量

7677

审稿时长

2.5 months

期刊介绍： Cancer Research, published by the American Association for Cancer Research (AACR), is a journal that focuses on impactful original studies, reviews, and opinion pieces relevant to the broad cancer research community. Manuscripts that present conceptual or technological advances leading to insights into cancer biology are particularly sought after. The journal also places emphasis on convergence science, which involves bridging multiple distinct areas of cancer research. With primary subsections including Cancer Biology, Cancer Immunology, Cancer Metabolism and Molecular Mechanisms, Translational Cancer Biology, Cancer Landscapes, and Convergence Science, Cancer Research has a comprehensive scope. It is published twice a month and has one volume per year, with a print ISSN of 0008-5472 and an online ISSN of 1538-7445. Cancer Research is abstracted and/or indexed in various databases and platforms, including BIOSIS Previews (R) Database, MEDLINE, Current Contents/Life Sciences, Current Contents/Clinical Medicine, Science Citation Index, Scopus, and Web of Science.