Krzysztof Śmiałkowski, Katarzyna Bednarska-Szczepaniak, Katarzyna Kulik, Justyna Suwara, Bohumir Grűner, Aleksander Foryś, Barbara Nawrot, Zbigniew J. Leśnikowski
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引用次数: 0
Abstract
Herein, we describe a new type of building block for nanoconstruction based on the composite of a boron cluster metal-complex (metallacarborane) and therapeutic nucleic acid and their assembly into functional nanoparticles with EGFR oncogene silencing activity. In this direction, a method for oligofunctionalization of a metallacarborane, 3,3’-cobalt-bis(1,2-dicarbollide)(−1) ion, and an automated method for synthesis of DNA-oligonucleotides attached to the metallacarborane core is developed. The obtained building blocks forms nanoparticles with a “chrysanthemum-like” topology that carry a slowly releasing antisense anti-EGFR oligonucleotide silencing EGFR gene efficiently in vitro in a pancreatic carcinoma cell line PANC-1.
ChemNanoMatEnergy-Energy Engineering and Power Technology
CiteScore
6.10
自引率
2.60%
发文量
236
期刊介绍：
ChemNanoMat is a new journal published in close cooperation with the teams of Angewandte Chemie and Advanced Materials, and is the new sister journal to Chemistry—An Asian Journal.
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