Comparison of Green-Synthesized Silver Nanoparticle Shampoo Created by Moringa and Bergamot Extraction Versus 2% Ketoconazole Shampoo for Scalp Seborrheic Dermatitis: A Prospective, Randomized, Double-Blinded, Controlled Trial

IF 3.4 4区医学 Q1 DERMATOLOGY

Dermatologic Therapy Pub Date : 2025-03-19 DOI:10.1155/dth/7166552

Piyakan Limtanyakul, Rithee Smithrithee, Panjaporn Wongwitthayakool, Malai Taweechotipatr, Pannawit Chottechathammanee, Somkiat Wattanasirichaigoon

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引用次数: 0

Abstract

Introduction: Seborrheic dermatitis (SD) is one of the most common relapsing–remitting scalp diseases. The symptoms of SD are relieved by many treatments, including antifungal shampoos such as zinc pyrithione, selenium sulfide, and azole shampoos. This study aimed to investigate the effects of a shampoo containing green-synthesized silver nanoparticles (AgNPs) in relieving the symptoms of SD.

Methods: Bergamot peel and moringa leaf extracts were green-synthesized to produce AgNP. Characteristic of AgNP particle was. The AgNPs were assessed to determine the minimum inhibitory concentration for Malassezia furfur and formulate the AgNP shampoo. Sixty patients with moderate to severe scalp SD were prospectively randomized into the 2% ketoconazole shampoo group (n = 30) and the AgNP shampoo group (n = 30). Scalp samples were collected for potassium hydroxide preparation and fungal culture for Malassezia species. The adherent scalp flaking score (ASFS), Dermatology Life Quality Index, and patient satisfaction were assessed.

Results: After the first week, the ASFS was significantly lower in the AgNP shampoo group compared with the 2% ketoconazole shampoo group (p = 0.014, p = 0.083). However, both shampoos significantly improved the ASFS at 2 and 4 weeks compared with the baseline. The improvements in the ASFS were not sustained at 1 month after discontinuing the use of either shampoo. The potassium hydroxide preparation and fungal culture could not identify the responsible fungus. The Dermatology Life Quality Index was significantly improved from baseline to Week 4 in the AgNP shampoo group (p = 0.026) but not the 2% ketoconazole shampoo group (p = 0.171). The overall patient-rated satisfaction levels were similar in the two groups. No adverse events were reported during the study, and there were no dropouts.

Conclusion: Green-synthesized AgNP shampoo created using bergamot and moringa extract exhibited comparable efficacy to 2% ketoconazole shampoo in treating scalp SD.

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辣木和佛手柠檬提取物合成的绿色合成纳米银洗发水与2%酮康唑洗发水治疗头皮脂流性皮炎的比较：一项前瞻性、随机、双盲、对照试验

脂溢性皮炎（SD）是最常见的复发缓解性头皮疾病之一。许多治疗方法可以缓解SD的症状，包括抗真菌洗发水，如吡硫锌、硫化硒和唑洗发水。本研究旨在探讨含有绿色合成银纳米粒子（AgNPs）的洗发水对缓解SD症状的影响。方法：绿色合成佛手柑皮和辣木叶提取物制备AgNP。AgNP粒子的特征为。对AgNP进行评估，以确定对马拉色菌的最低抑制浓度，并配制AgNP洗发水。60例中重度头皮SD患者前瞻性随机分为2%酮康唑洗发水组（n = 30）和AgNP洗发水组（n = 30）。采集头皮样品进行氢氧化钾制备和马拉色菌真菌培养。评估粘附性头皮脱落评分（ASFS）、皮肤科生活质量指数（Dermatology Life Quality Index）和患者满意度。结果：第1周后，AgNP洗发水组ASFS明显低于2%酮康唑洗发水组（p = 0.014, p = 0.083）。然而，与基线相比，两种洗发水在第2周和第4周时显著改善了ASFS。在停止使用任何一种洗发水后1个月，ASFS的改善都没有持续。氢氧化钾制备和真菌培养均不能鉴定出致病真菌。AgNP洗发水组皮肤病学生活质量指数从基线到第4周显著改善（p = 0.026），但2%酮康唑洗发水组没有（p = 0.171）。两组患者总体满意度相似。在研究期间没有不良事件报告，也没有中途退出。结论：佛手柑和辣木提取物制备的绿色合成AgNP洗发水治疗头皮SD的疗效与2%酮康唑洗发水相当。

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来源期刊

Dermatologic Therapy 医学-皮肤病学

CiteScore

7.00

自引率

8.30%

发文量

711

审稿时长

3 months

期刊介绍： Dermatologic Therapy has been created to fill an important void in the dermatologic literature: the lack of a readily available source of up-to-date information on the treatment of specific cutaneous diseases and the practical application of specific treatment modalities. Each issue of the journal consists of a series of scholarly review articles written by leaders in dermatology in which they describe, in very specific terms, how they treat particular cutaneous diseases and how they use specific therapeutic agents. The information contained in each issue is so practical and detailed that the reader should be able to directly apply various treatment approaches to daily clinical situations. Because of the specific and practical nature of this publication, Dermatologic Therapy not only serves as a readily available resource for the day-to-day treatment of patients, but also as an evolving therapeutic textbook for the treatment of dermatologic diseases.