{"title":"Formulation of Nanogel Loaded with Lantana montevidensis-Incorporated Silver Nanoparticles: A Bio-Inspired Approach to Rheumatoid Arthritis Therapy","authors":"Sourabh Malabade, Preeti Salve, Pranay S. Shirke","doi":"10.1007/s12247-025-09974-7","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>This study aims to revolutionize rheumatoid arthritis (RA) treatment by developing an optimized silver nanoparticle (AgNP)-loaded nanogel for targeted transdermal delivery. RA is a chronic autoimmune disorder requiring innovative therapies to address the limitations of existing treatments, including systemic side effects and incomplete symptom control. The research focuses on engineering a nanogel formulation to achieve sustained drug release and enhanced therapeutic efficacy.</p><h3>Methods</h3><p>The nanogel was designed using a central composite design to optimize key physicochemical properties, including viscosity, spreadability, and pH, ensuring ease of application, skin compatibility, and maximal coverage. The incorporation of <i>Lantana montevidensis</i> aqueous extract further enhances the formulation’s therapeutic potential. This plant extract is known for its anti-inflammatory properties, providing a synergistic effect with the AgNPs. The therapeutic potential of the nanogel was assessed through in vitro proteinase inhibition, in vivo anti-inflammatory and anti-arthritic studies.</p><h3>Results</h3><p>The nanogel demonstrated superior anti-inflammatory and anti-arthritic efficacy compared to conventional treatments. Sustained drug release was evaluated in vitro, achieving a controlled release profile of 95.36% over 8 h. It significantly reduced edema, preserved joint structure, and inhibited proteinase activity, preventing cartilage degradation. The sustained release profile minimized dosing frequency and potential side effects, ensuring consistent therapeutic levels at the target site.</p><h3>Conclusion</h3><p>The optimized AgNP-loaded nanogel represents a breakthrough in RA treatment, offering a biocompatible and stable formulation with enhanced therapeutic outcomes. Its controlled drug delivery and synergistic anti-inflammatory effects provide a promising approach for improving RA management and patient quality of life.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 2","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Innovation","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12247-025-09974-7","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose
This study aims to revolutionize rheumatoid arthritis (RA) treatment by developing an optimized silver nanoparticle (AgNP)-loaded nanogel for targeted transdermal delivery. RA is a chronic autoimmune disorder requiring innovative therapies to address the limitations of existing treatments, including systemic side effects and incomplete symptom control. The research focuses on engineering a nanogel formulation to achieve sustained drug release and enhanced therapeutic efficacy.
Methods
The nanogel was designed using a central composite design to optimize key physicochemical properties, including viscosity, spreadability, and pH, ensuring ease of application, skin compatibility, and maximal coverage. The incorporation of Lantana montevidensis aqueous extract further enhances the formulation’s therapeutic potential. This plant extract is known for its anti-inflammatory properties, providing a synergistic effect with the AgNPs. The therapeutic potential of the nanogel was assessed through in vitro proteinase inhibition, in vivo anti-inflammatory and anti-arthritic studies.
Results
The nanogel demonstrated superior anti-inflammatory and anti-arthritic efficacy compared to conventional treatments. Sustained drug release was evaluated in vitro, achieving a controlled release profile of 95.36% over 8 h. It significantly reduced edema, preserved joint structure, and inhibited proteinase activity, preventing cartilage degradation. The sustained release profile minimized dosing frequency and potential side effects, ensuring consistent therapeutic levels at the target site.
Conclusion
The optimized AgNP-loaded nanogel represents a breakthrough in RA treatment, offering a biocompatible and stable formulation with enhanced therapeutic outcomes. Its controlled drug delivery and synergistic anti-inflammatory effects provide a promising approach for improving RA management and patient quality of life.
期刊介绍：
The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories:
Materials science,
Product design,
Process design, optimization, automation and control,
Facilities; Information management,
Regulatory policy and strategy,
Supply chain developments ,
Education and professional development,
Journal of Pharmaceutical Innovation publishes four issues a year.
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