Native and modified β-cyclodextrins as solubility enhancers for methotrexate loaded in iota-carrageenan hydrogel

IF 5.3 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Liquids Pub Date : 2025-03-17 DOI:10.1016/j.molliq.2025.127407

Nataliya Kochkina, Maria Nikitina, Irina Terekhova

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引用次数: 0

Abstract

This study focuses on the development of composite hydrogel of iota-carrageenan loaded with methotrexate – mainstay therapeutic agent administered for treatment of autoimmune disorders and several types of cancer. Despite the good efficiency, methotrexate exhibits serious and sometime life-threatening adverse effects. Topical administration of methotrexate in the form of hydrogels can decrease the high toxicity of this drug. However, low aqueous solubility of methotrexate significantly limits its loading efficiency into hydrogels. In this connection, modified β-cyclodextrins, being more convenient for practical use in comparison with the native cyclodextrins, were employed to improve the aqueous solubility of methotrexate. To this end, (2-hydroxy-3-N,N,N-trimethylamino)propyl-β-cyclodextrin (NH₂-βCD) displaying more pronounced solubilizing effect compared with methyl- and hydroxypropyl-β-cyclodextrins was used as solubilizer for methotrexate loaded into iota-carrageenan hydrogel. The prepared composite hydrogels were analyzed for their rheological and pharmaceutically important parameters. It was demonstrated that NH₂-βCD affects the gelation process due to the binding with polar groups of iota-carrageenan. Complex formation of methotrexate with NH₂-βCD has influence on the release and permeation activity of the drug. The obtained results showed that methotrexate loaded in iota-carrageenan hydrogel exhibits a sustained release.

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来源期刊

Journal of Molecular Liquids 化学-物理：原子、分子和化学物理

CiteScore

10.30

自引率

16.70%

发文量

2597

审稿时长

78 days

期刊介绍： The journal includes papers in the following areas: – Simple organic liquids and mixtures – Ionic liquids – Surfactant solutions (including micelles and vesicles) and liquid interfaces – Colloidal solutions and nanoparticles – Thermotropic and lyotropic liquid crystals – Ferrofluids – Water, aqueous solutions and other hydrogen-bonded liquids – Lubricants, polymer solutions and melts – Molten metals and salts – Phase transitions and critical phenomena in liquids and confined fluids – Self assembly in complex liquids.– Biomolecules in solution The emphasis is on the molecular (or microscopic) understanding of particular liquids or liquid systems, especially concerning structure, dynamics and intermolecular forces. The experimental techniques used may include: – Conventional spectroscopy (mid-IR and far-IR, Raman, NMR, etc.) – Non-linear optics and time resolved spectroscopy (psec, fsec, asec, ISRS, etc.) – Light scattering (Rayleigh, Brillouin, PCS, etc.) – Dielectric relaxation – X-ray and neutron scattering and diffraction. Experimental studies, computer simulations (MD or MC) and analytical theory will be considered for publication; papers just reporting experimental results that do not contribute to the understanding of the fundamentals of molecular and ionic liquids will not be accepted. Only papers of a non-routine nature and advancing the field will be considered for publication.