Thermochemical parameters of phase transitions of some low volatile sulfonamides prone to polymorphism

IF 5.3 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Liquids Pub Date : 2025-03-18 DOI:10.1016/j.molliq.2025.127420

Ruslan N. Nagrimanov , Almaz R. Italmasov , Igor O. Nasibullin , Radik A. Larionov , Vladimir A. Burilov , Khasan R. Khayarov , Alexander V. Gerasimov

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引用次数: 0

Abstract

The determination of the thermochemical parameters of phase transitions of sulfonamides is a difficult task due to their low volatility, thermal stability and high tendency to polymorphism. In this work, we have proposed an approach that allows to control the polymorphic form of studied sample by fast scanning calorimetry. Well reproducible vapour pressure values over a wide temperature range were obtained by fast scanning calorimetry. The temperature dependence of the vapour pressure of the studied sulfonamides were used to determine the enthalpy of sublimation of benzenesulfonamide, sulfanilamide, sulfacetamide, sulfamerazine, sulfamethizole and sulfamethizole derivative synthesized in the present work. The solution calorimetry method was improved to verify the reliability of the sublimation enthalpies of sulfonamides obtained using fast scanning calorimetry. By the combined application of fast scanning calorimetry and solution calorimetry methods, we were able to obtain a consistent data set of sublimation enthalpies for a series of sulfonamides.

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来源期刊

Journal of Molecular Liquids 化学-物理：原子、分子和化学物理

CiteScore

10.30

自引率

16.70%

发文量

2597

审稿时长

78 days

期刊介绍： The journal includes papers in the following areas: – Simple organic liquids and mixtures – Ionic liquids – Surfactant solutions (including micelles and vesicles) and liquid interfaces – Colloidal solutions and nanoparticles – Thermotropic and lyotropic liquid crystals – Ferrofluids – Water, aqueous solutions and other hydrogen-bonded liquids – Lubricants, polymer solutions and melts – Molten metals and salts – Phase transitions and critical phenomena in liquids and confined fluids – Self assembly in complex liquids.– Biomolecules in solution The emphasis is on the molecular (or microscopic) understanding of particular liquids or liquid systems, especially concerning structure, dynamics and intermolecular forces. The experimental techniques used may include: – Conventional spectroscopy (mid-IR and far-IR, Raman, NMR, etc.) – Non-linear optics and time resolved spectroscopy (psec, fsec, asec, ISRS, etc.) – Light scattering (Rayleigh, Brillouin, PCS, etc.) – Dielectric relaxation – X-ray and neutron scattering and diffraction. Experimental studies, computer simulations (MD or MC) and analytical theory will be considered for publication; papers just reporting experimental results that do not contribute to the understanding of the fundamentals of molecular and ionic liquids will not be accepted. Only papers of a non-routine nature and advancing the field will be considered for publication.