From cobalt(II), nickel(II) and copper(II) (2-thio)barbiturates to their imidazole-based complex salts: Synthesis, structure, physicochemical and biological properties

IF 2.7 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Inorganica Chimica Acta Pub Date : 2025-03-07 DOI:10.1016/j.ica.2025.122643

Alexander P. Lakeev , Taisiya S. Sukhikh , Alena G. Korzhova , Olga Yu. Rybalkina , Evgeny E. Buyko , Natalia M. Korotchenko , Irina A. Kurzina

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引用次数: 0

Abstract

A series of metal(II) complexes based on 1,3-diazinane-2,4,6-trione (H₂BA, C₄H₄N₂O₃) or 2-sulfanylidene-1,3-diazinane-4,6-dione (H₂TBA, C₄H₄N₂O₂S) with the formula [M(H₂O)₄(HBA)₂] (1, 2), [Cu(H₂O)₃(HBA)₂] (3) and [M(H₂O)₂(HTBA)₂] (4, 5) (M = Co, Ni) were synthesized. These compounds were then used to obtain novel complex salts [M(H₂O)_m(Im)_n](H(T)BA)₂ · pH₂O (m = 0 or 2, n = 4 or 6, p = 0, 2 or 4) and [Cu(H₂O)(Im)₄](HBA)₂ · 3H₂O, where Im is 1H-imidazole (C₃H₄N₂). The isolated products were characterized using elemental analysis, FT-IR spectroscopy, XRD and TG–DSC. Complexes 1–5 were slightly soluble in water (–logK_sp ranged from 5.10 for 5 to 7.45 for 4) and started to undergo oxidative degradation at 220–300 °C. The presence of [MH(T)BA]⁺ species in acidic solutions was revealed, and their β₁₁ values, which varied within a range of ∼2–3 log units, were determined using the solubility method and pH-metry. Metal(II) imidazole complexes, with some exceptions, were more soluble than 1–5, but their decomposition started to occur at 130–175 and 325–450 °C for the Im and H(T)BAˉ moieties, respectively. The preservation of their inner coordination sphere after dissolution in water was confirmed by UV–Vis spectroscopy. The spectra had typical λ_max values for metal(II)–Im systems: ∼500 nm (Co²⁺), ∼632 nm (Ni²⁺) and ∼631 nm (Cu²⁺). In the crystal structures of salts, 3D supramolecular frameworks were assembled by water molecules, complex cations and corresponding anions through hydrogen bonding. During biological testing, only nickel(II) imidazole complexes demonstrated enhanced bacteriostatic activity against E. coli. The cytotoxicity of copper-based compounds was significantly higher for SKOV3 cancer cells than against HepG2 cells.

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来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.