Metabolomics profiling in venous thromboembolism and its chronic sequelae - A systematic review

IF 3.7 3区医学 Q1 HEMATOLOGY

Thrombosis research Pub Date : 2025-03-20 DOI:10.1016/j.thromres.2025.109309

Zahra Amirsardari , Asal Khalili , Mohammadhasan Sharafi , Reza Mehrizi , Shana Ahadi , Amirhossein Roshanshad , Mahshid Malakootian

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引用次数: 0

Abstract

Background

High-throughput metabolomics studies have advanced the identification of novel biomarkers and enhanced the understanding of the pathogenesis of venous thrombosis. This systematic review aims to summarize metabolomics research conducted on venous thromboembolism (VTE), as well as its chronic sequelae, including chronic thromboembolic pulmonary hypertension (CTEPH) and post-thrombotic syndrome (PTS), encompassing both pre-clinical and clinical investigations.

Methods

A systematic search using relevant keywords related to metabolomics profiling and venous thromboembolism was conducted across four databases (PubMed, Embase, Scopus, and Web of Science). Quality assessment for animal studies was performed using SYRCLE, and for human studies, QUADOMICS was used. The study protocol is registered in PROSPERO under registry code CRD42024529490.

Results

Multiple metabolic disturbances were identified in various venous thrombotic conditions, including dysregulations in cellular respiration and the metabolism of carbohydrates, amino acids, lipids, and nucleic acids. Notably, altered levels of serum amino acids and their derivatives were frequently reported in patients with venous thrombosis, though findings regarding specific amino acids such as alanine, arginine, and tryptophan were inconsistent. Additionally, disruptions in tricarboxylic acid (TCA) cycle metabolites were commonly observed. Pathway enrichment analysis revealed significant involvement of several metabolic pathways, including valine, leucine, and isoleucine biosynthesis; alanine and aspartate metabolism; d-glutamine and D-glutamate metabolism; and arginine metabolism.

Conclusions

This systematic review offers a comprehensive overview of metabolomics research in venous thromboembolism and its chronic sequelae, identifying the most affected metabolic pathways associated with disease progression.

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静脉血栓栓塞及其慢性后遗症的代谢组学分析-系统综述

高通量代谢组学研究促进了新的生物标志物的鉴定，增强了对静脉血栓形成机制的理解。本系统综述旨在总结静脉血栓栓塞（VTE）及其慢性后遗症，包括慢性血栓栓塞性肺动脉高压（CTEPH）和血栓后综合征（PTS）的代谢组学研究，包括临床前和临床研究。方法在PubMed、Embase、Scopus和Web of Science 4个数据库中对代谢组学分析和静脉血栓栓塞相关关键词进行系统检索。动物研究的质量评估使用cycle，人类研究使用QUADOMICS。研究方案在PROSPERO注册，注册码为CRD42024529490。结果在不同的静脉血栓形成条件下发现多种代谢紊乱，包括细胞呼吸和碳水化合物、氨基酸、脂质和核酸的代谢失调。值得注意的是，静脉血栓患者血清氨基酸及其衍生物水平的改变经常被报道，尽管关于特定氨基酸（如丙氨酸、精氨酸和色氨酸）的发现不一致。此外，通常观察到三羧酸（TCA）循环代谢物的破坏。途径富集分析揭示了几种代谢途径的显著参与，包括缬氨酸、亮氨酸和异亮氨酸的生物合成；丙氨酸和天冬氨酸代谢；d-谷氨酰胺和d-谷氨酸代谢；还有精氨酸代谢。本系统综述全面概述了静脉血栓栓塞及其慢性后遗症的代谢组学研究，确定了与疾病进展相关的最受影响的代谢途径。

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来源期刊

Thrombosis research 医学-外周血管病

CiteScore

14.60

自引率

4.00%

发文量

364

审稿时长

31 days

期刊介绍： Thrombosis Research is an international journal dedicated to the swift dissemination of new information on thrombosis, hemostasis, and vascular biology, aimed at advancing both science and clinical care. The journal publishes peer-reviewed original research, reviews, editorials, opinions, and critiques, covering both basic and clinical studies. Priority is given to research that promises novel approaches in the diagnosis, therapy, prognosis, and prevention of thrombotic and hemorrhagic diseases.