Covalent organic frameworks in cancer theranostics: advancing biomarker detection and tumor-targeted therapy

IF 6.9 3区 医学 Q1 CHEMISTRY, MEDICINAL
Sonia Iranpour, Amir Abrishami, Amir Sh. Saljooghi
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引用次数: 0

Abstract

In recent years, covalent organic frameworks (COFs) have garnered considerable attention in the field of onco-nanotechnology as a new type of nanoporous construct due to their promising physicochemical properties, ease of modification, and ability to be coupled with several moieties and therapeutic molecules. They can not only be used as biocompatible nanocarriers to deliver therapeutic payloads to the tumor zone selectively but can also be combined with a variety of therapeutic modalities to achieve the desired treatments. This review comprehensively presented recent achievements and progress in COF-based cancer diagnosis, detection, and cancer therapy to provide a better prospect for further research. Herein our primary emphasis lies on exploring the application of COFs as potential sensors for cancer-derived biomarkers that have received comparatively less attention in previous discussions. While the utilization of COFs in solid tumor therapy has faced significant challenges in scientific research and clinical applications, we reviewed the most promising features that underscore their potential in cancer theranostics.

共价有机框架在癌症治疗中的应用:推进生物标志物检测和肿瘤靶向治疗。
近年来,共价有机框架(COFs)作为一种新型的纳米孔结构在肿瘤纳米技术领域引起了广泛的关注,因为它具有良好的物理化学性质,易于修饰,并且能够与多个部分和治疗分子偶联。它们不仅可以作为生物相容性纳米载体,选择性地将治疗有效载荷传递到肿瘤区域,而且还可以与各种治疗方式相结合,以实现所需的治疗。本文综述了近年来基于cof的肿瘤诊断、检测和治疗的研究进展,以期为今后的研究提供更好的前景。在这里,我们的主要重点在于探索COFs作为癌症生物标志物的潜在传感器的应用,这些标志物在之前的讨论中受到的关注相对较少。尽管COFs在实体肿瘤治疗中的应用在科学研究和临床应用中面临着重大挑战,但我们回顾了其在癌症治疗中最具潜力的特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
13.40
自引率
9.00%
发文量
48
审稿时长
3.3 months
期刊介绍: Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.
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