Natural products targeting regulated cell deaths for adriamycin-induced cardiotoxicity.

IF 6.1 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-03-21 DOI:10.1038/s41420-025-02389-w

Zheng Wang, Yanli Zhu, Yu Yao, Wenyu Zhang, Bo Wang, Jing Wang, Yang Yang, Liwen Liu

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引用次数: 0

Abstract

Adriamycin (ADR), as an anti-cancer drug in routine clinical application, is utilized to treat various cancers such as ovarian cancer, hematological malignant tumor, and endometrial carcinoma. However, its serious dose-dependent cardiotoxicity extremely limits its clinical application. Currently, there remains a dearth of therapeutic agents to mitigate ADR-induced cardiotoxicity. Extensive research has demonstrated that ADR can simultaneously trigger various regulated cell death (RCD) pathways, such as apoptosis, autophagy, ferroptosis, necroptosis, and pyroptosis. Therefore, drugs targeting these RCD pathways may represent effective strategies for treating ADR-induced cardiotoxicity. Natural products, with their wide availability, low cost, and diverse pharmacological activities, have increasingly gained attention. Various natural products, including polyphenols, flavonoids, terpenoids, and alkaloids, can target the RCD pathways involved in ADR-induced cardiotoxicity. Furthermore, these natural products have exhibited excellent properties in preclinical studies or in vitro experiments. This review summarizes the mechanisms of RCD in ADR-induced cardiotoxicity and systematically reviews the natural products targeting these RCD pathways. Finally, we propose future research directions of natural products in this field.

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针对阿霉素诱导的心脏毒性的调节细胞死亡的天然产物。

阿霉素（ADR）作为临床常规应用的抗癌药物，用于治疗卵巢癌、血液恶性肿瘤、子宫内膜癌等多种癌症。但其严重的剂量依赖性心脏毒性极大地限制了其临床应用。目前，仍然缺乏治疗药物来减轻adr引起的心脏毒性。大量研究表明，ADR可同时触发多种受调控的细胞死亡（RCD）途径，如凋亡、自噬、铁下垂、坏死下垂和焦下垂。因此，靶向这些RCD途径的药物可能是治疗adr诱导的心脏毒性的有效策略。天然产物以其可获得性广、成本低、药理活性多样等特点，越来越受到人们的重视。多种天然产物，包括多酚类、黄酮类、萜类和生物碱，可靶向adr诱导心脏毒性的RCD途径。此外，这些天然产物在临床前研究或体外实验中表现出优异的性能。本文综述了RCD在adr诱导的心脏毒性中的作用机制，并系统地综述了靶向这些RCD途径的天然产物。最后，提出了该领域天然产物未来的研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.