Actinic cheilitis: Do stem cells have a role in its management? A case series

IF 1.7 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
CY. Chieng , N. Mannapperuma , A. Sayan , V. Ilankovan
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引用次数: 0

Abstract

Actinic cheilitis (AC) is a premalignant mucosal lip condition that mainly affects the lower lip and has a high propensity of malignant transformation into squamous cell carcinoma. There is no gold standard for its management, but early intervention aims to minimise the risk of malignant transformation. Here we report our experience of utilising nanofat grafting in the management of AC. Retrospective data analysis was carried out between 2020 and 2024. Patients diagnosed with AC were treated with nanofat grafting. The nanofat preparation was harvested from the abdomen and prepared using the PureGraft® filtration system (Bimini Health Tech), and was infiltrated into the lips in two layers. Outcomes were assessed clinically. Seven patients were included in our analysis with a mean follow up of 23 months. All patients had had previous treatment for AC such as topical 5-fluororacil, steroids, laser ablation, and cryotherapy. Five of the seven received simultaneous nanofat grafting followed by erbium laser resurfacing at the same appointment. The others had nanofat grafting after laser resurfacing. Following the procedure all the patients had no further cracks, ulcerations, or erosions of the lips, with a good definition of the vermilion border, and all patients remained symptom free. The combination of nanofat grafting and laser resurfacing provides an alternative minimally invasive solution for patients with persistent AC. We have formulated an algorithm for management based on our experience.
光化性唇炎:干细胞在其治疗中起作用吗?一个案例系列。
光化性唇炎(AC)是一种主要影响下唇的粘膜唇癌前病变,有很高的恶性转化为鳞状细胞癌的倾向。对于其管理没有黄金标准,但早期干预旨在将恶性转化的风险降至最低。在这里,我们报告了我们在AC管理中利用纳米脂肪嫁接的经验。回顾性数据分析在2020年至2024年间进行。确诊为AC的患者采用纳米脂肪移植治疗。纳米脂肪从腹部采集,使用PureGraft®过滤系统(Bimini Health Tech)制备,并分两层渗透到嘴唇中。临床评估结果。7例患者纳入我们的分析,平均随访23个月。所有患者之前都接受过AC治疗,如外用5-氟尿嘧啶、类固醇、激光消融和冷冻治疗。7名患者中有5名同时接受纳米脂肪移植,随后在同一时间接受铒激光表面置换。其余患者在激光表面修复后进行纳米脂肪移植。手术后,所有患者的嘴唇都没有进一步的裂缝、溃疡或糜烂,朱红色边界清晰,所有患者都没有症状。纳米脂肪移植结合激光表面置换为顽固性AC患者提供了另一种微创解决方案。我们根据经验制定了一套管理算法。
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来源期刊
CiteScore
3.60
自引率
16.70%
发文量
256
审稿时长
6 months
期刊介绍: Journal of the British Association of Oral and Maxillofacial Surgeons: • Leading articles on all aspects of surgery in the oro-facial and head and neck region • One of the largest circulations of any international journal in this field • Dedicated to enhancing surgical expertise.
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