A Review on Radiologic Hot Cross Bun Sign and Related Clinical Conditions.

IF 2.7 3区医学 Q3 NEUROSCIENCES

Cerebellum Pub Date : 2025-03-21 DOI:10.1007/s12311-025-01830-1

Mehri Salari, Mohammad Golzarian, Kamran Rezaei, Masoud Etemadifar

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引用次数: 0

Abstract

The hot cross bun (HCB) sign is a cruciform-shaped hyperintensity on axial T2 weighted-image magnetic resonance imaging (MRI), mostly reported with multiple system atrophy (MSA). However, several other diagnoses were reported with this radiologic manifestation as well. This review investigates the wide spectrum of disorders in which the HCB sign has been reported as a positive radiologic manifestation. This narrative review was conducted using the PubMed database. Studies reporting the HCB sign in their manuscript are included in this manuscript. 83 studies with available full text met the inclusion criteria for this review. The total number of reported patients with HCB sign is addressed in the manuscript. In addition to MSA, the HCB sign has been reported in various other disorders, including spinocerebellar ataxia, malignancies, infections, autoimmune disorders, and some vascular and ischemic changes. Any disorder involving the pontocerebellar fibers can manifest the HCB sign following the gliosis changes or infarction-mediated damage to the region, whether due to gliosis changes. The range of diseases linked to the HCB sign is broader than previously recognized, as numerous disorders affect the transverse pontocerebellar fibers and cause radiologic HCB manifestation. MSA remains the most common condition; however, clinicians should consider alternate differential diagnoses in patients displaying the HCB sign in whom clinical presentation is not typical of MSA.

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影像学热十字包征及相关临床情况综述。

热十字包征（HCB）是T2轴向加权磁共振成像（MRI）上的十字形高信号，多伴有多系统萎缩（MSA）。然而，其他一些诊断也有这种放射学表现。本综述调查了广泛的疾病，其中HCB标志已被报道为放射学阳性表现。这篇叙述性综述是使用PubMed数据库进行的。报告其手稿中有HCB标志的研究包括在本手稿中。83项有全文的研究符合本综述的纳入标准。报告的HCB患者总数在手稿中有详细说明。除MSA外，HCB征象也见于其他疾病，包括脊髓小脑性共济失调、恶性肿瘤、感染、自身免疫性疾病以及一些血管和缺血性改变。任何涉及桥小脑纤维的疾病都可以在神经胶质瘤改变或梗死介导的区域损伤后表现出HCB信号，无论是由于神经胶质瘤改变。与HCB体征相关的疾病范围比以前认识到的更广泛，因为许多疾病影响桥小脑横向纤维并引起放射学上的HCB表现。MSA仍然是最常见的疾病；然而，临床医生应该考虑在临床表现不典型的MSA患者中显示HCB体征的其他鉴别诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cerebellum 医学-神经科学

CiteScore

6.40

自引率

14.30%

发文量

150

审稿时长

4-8 weeks

期刊介绍： Official publication of the Society for Research on the Cerebellum devoted to genetics of cerebellar ataxias, role of cerebellum in motor control and cognitive function, and amid an ageing population, diseases associated with cerebellar dysfunction. The Cerebellum is a central source for the latest developments in fundamental neurosciences including molecular and cellular biology; behavioural neurosciences and neurochemistry; genetics; fundamental and clinical neurophysiology; neurology and neuropathology; cognition and neuroimaging. The Cerebellum benefits neuroscientists in molecular and cellular biology; neurophysiologists; researchers in neurotransmission; neurologists; radiologists; paediatricians; neuropsychologists; students of neurology and psychiatry and others.