Investigation of neuro-vascular reactivity on fMRI study during visual activation in people with multiple sclerosis using EEG and hypercapnia challenge

IF 3.2 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Medical physics Pub Date : 2025-03-21 DOI:10.1002/mp.17772

Wanyong Shin, Balu Krishnan, Ajay Nemani, Daniel Ontaneda, Mark J. Lowe

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Abstract

Background

People with multiple sclerosis (MS) exhibit a different pattern of blood oxygenation level-dependent (BOLD) activation on functional magnetic resonance imaging (fMRI) studies when compared to healthy control (HC).

Purpose

The objective of this study is to determine whether observed differences in BOLD activation between people with MS (pwMS) and HC participants are due to the differences of neurovascular coupling, cerebral blood flow (CBF) or actual neuronal activity.

Methods

We investigated the neuronal activation in pwMS (n = 11) and age- and sex-matched HC participants (n = 15) using simultaneous electroencephalogram (EEG) and fMRI measures during a visual task (VT) and hypercapnia condition.

Results

Significant neurovascular coupling is observed in both HC and pwMS. Neuro-vascular coupling ratios are not significantly different between groups. However, we observe significantly lower CBF increase during VT and higher quantitative CBF at a rest state in pwMS than in HC (p < 0.05). From the multiple regression model, in HC group, we found that the BOLD contrast change during VT is best predicted by the EEG power change during VT (Student t-score = 2.64, p = 0.022), and the CBF change during hypercapnia (Student t-score = 2.59, p = 0.024). In pwMS, the BOLD contrast change during VT is negatively predicted by the CBF change during VT (Student t-score = −4.02, p = 0.003).

Conclusion

These findings could explain that BOLD activation in pwMS is mainly determined by the blood flow change during activation rather than the direct neuronal activation measures or hemodynamic vascular reactivity during hypercapnia challenge, suggesting that altered vasodilatory effects in response to task activation in pwMS might be linked to impaired cerebral hemodynamics, possibly leading to the widely observed abnormal BOLD activation in fMRI studies of pwMS.

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利用脑电图和高碳酸血症刺激研究多发性硬化症患者视觉激活过程中fMRI研究的神经血管反应性。

背景：与健康对照（HC）相比，多发性硬化症（MS）患者在功能磁共振成像（fMRI）研究中表现出不同的血氧水平依赖性（BOLD）激活模式。目的：本研究的目的是确定观察到的MS （pwMS）和HC参与者之间BOLD激活的差异是由于神经血管耦合、脑血流量（CBF）或实际神经元活动的差异。方法：采用同步脑电图（EEG）和功能磁共振成像（fMRI）测量视觉任务（VT）和高碳酸血症时pwMS （n = 11）和年龄和性别匹配的HC （n = 15）参与者的神经元激活情况。结果：HC和pwMS均有明显的神经血管耦合。各组间神经血管耦合率无显著差异。然而，我们观察到，与HC相比，pwMS在VT期间的CBF增加明显较低，而静止状态下的CBF数量较高(p)。这些发现可以解释pwMS中的BOLD激活主要由激活过程中的血流变化决定，而不是由高碳酸血症挑战时直接的神经元激活措施或血流动力学血管反应性决定，这表明pwMS中任务激活时血管舒张作用的改变可能与脑血流动力学受损有关，这可能导致在pwMS的fMRI研究中广泛观察到异常的BOLD激活。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical physics 医学-核医学

CiteScore

6.80

自引率

15.80%

发文量

660

审稿时长

1.7 months

期刊介绍： Medical Physics publishes original, high impact physics, imaging science, and engineering research that advances patient diagnosis and therapy through contributions in 1) Basic science developments with high potential for clinical translation 2) Clinical applications of cutting edge engineering and physics innovations 3) Broadly applicable and innovative clinical physics developments Medical Physics is a journal of global scope and reach. By publishing in Medical Physics your research will reach an international, multidisciplinary audience including practicing medical physicists as well as physics- and engineering based translational scientists. We work closely with authors of promising articles to improve their quality.