Evaluating the Macroeconomic Burden of Hepatitis B and the Gains From Timely Coverage Investments in China

IF 6 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Liver International Pub Date : 2025-03-21 DOI:10.1111/liv.70054

Yun Bao, Ying Chen, Huajie Jin, Chi Zhang, Lingli Zhang, Bin Wu

{"title":"Evaluating the Macroeconomic Burden of Hepatitis B and the Gains From Timely Coverage Investments in China","authors":"Yun Bao, Ying Chen, Huajie Jin, Chi Zhang, Lingli Zhang, Bin Wu","doi":"10.1111/liv.70054","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Hepatitis B (HBV) continues to pose a significant public health challenge in China. This study aimed to assess the macroeconomic burden of HBV and its impact on gross domestic product (GDP) in China and estimate the potential benefits of early and enhanced interventions between 2023 and 2050.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A compartmental model was employed to simulate HBV transmission, progression, and patient care. The model was structured by age and sex to calculate the costs and benefits associated with achieving World Health Organisation (WHO) coverage targets by 2030, 2040, and 2050. The macroeconomic burden was estimated using a health-augment model, based on a counterfactual scenario. All costs were reported in 2023 US dollars.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The estimated macroeconomic burden of HBV in China from 2023 to 2050 is projected to reach $2.52 trillion, representing 0.33% of the country's total GDP. Achieving the WHO HBV diagnosis and treatment coverage targets by 2030 could, over the same period, reduce cumulative CHB incidence by 0.27(95% UI 0.24–0.30) million, prevent 1.08(95% UI 0.91–1.24) million HCC cases, avert 2.98(95% UI 2.83–3.14) million HBV-related deaths, and contribute an additional $0.85 trillion (95% UI $0.78–$0.93 trillion) to GDP by 2050.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>These findings underscore the importance of early and increased interventions in the diagnosis and treatment of HBV to mitigate the long-term impact of CHB, HCC, and HBV-related deaths. Achieving WHO coverage targets not only optimises disease burden but also promotes economic growth.</p>\n </section>\n </div>","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 4","pages":""},"PeriodicalIF":6.0000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Liver International","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/liv.70054","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Hepatitis B (HBV) continues to pose a significant public health challenge in China. This study aimed to assess the macroeconomic burden of HBV and its impact on gross domestic product (GDP) in China and estimate the potential benefits of early and enhanced interventions between 2023 and 2050.

Methods

A compartmental model was employed to simulate HBV transmission, progression, and patient care. The model was structured by age and sex to calculate the costs and benefits associated with achieving World Health Organisation (WHO) coverage targets by 2030, 2040, and 2050. The macroeconomic burden was estimated using a health-augment model, based on a counterfactual scenario. All costs were reported in 2023 US dollars.

Results

The estimated macroeconomic burden of HBV in China from 2023 to 2050 is projected to reach $2.52 trillion, representing 0.33% of the country's total GDP. Achieving the WHO HBV diagnosis and treatment coverage targets by 2030 could, over the same period, reduce cumulative CHB incidence by 0.27(95% UI 0.24–0.30) million, prevent 1.08(95% UI 0.91–1.24) million HCC cases, avert 2.98(95% UI 2.83–3.14) million HBV-related deaths, and contribute an additional $0.85 trillion (95% UI $0.78–$0.93 trillion) to GDP by 2050.

Conclusions

These findings underscore the importance of early and increased interventions in the diagnosis and treatment of HBV to mitigate the long-term impact of CHB, HCC, and HBV-related deaths. Achieving WHO coverage targets not only optimises disease burden but also promotes economic growth.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Liver International 医学-胃肠肝病学

CiteScore

13.90

自引率

4.50%

发文量

348

审稿时长

2 months

期刊介绍： Liver International promotes all aspects of the science of hepatology from basic research to applied clinical studies. Providing an international forum for the publication of high-quality original research in hepatology, it is an essential resource for everyone working on normal and abnormal structure and function in the liver and its constituent cells, including clinicians and basic scientists involved in the multi-disciplinary field of hepatology. The journal welcomes articles from all fields of hepatology, which may be published as original articles, brief definitive reports, reviews, mini-reviews, images in hepatology and letters to the Editor.