The Atrial FibriLlatiOn Registry (FLOW-AF): Patient Characteristics, Treatment Patterns, and Outcomes in Egypt.
IF 3
Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
引用次数: 0
Abstract
Introduction: Real-world data on atrial fibrillation (AF) in the Middle East and North Africa (MENA) region, including Egypt, are sparse. The aim of the FLOW-AF registry was to evaluate the characteristics, treatment patterns, and clinical and economic outcomes of newly diagnosed non-valvular atrial fibrillation (NVAF) patients within the MENA region, including Egypt.
Methods: This multicenter, prospective, observational registry enrolled newly diagnosed patients with NVAF from January 2020 to December 2022 at eight private-sector healthcare centers in Egypt. Data were collected at enrollment (baseline), and then at 6-month and 12-month follow-up. Baseline data included demographics, AF characteristics, medical history, and antithrombotic treatment patterns. Follow-up data included clinical events, healthcare resource utilization, and related costs.
Results: A total of 723 patients were enrolled. Overall, 51.87% were females, and the mean age was 61.9 years. All patients attended the private health sector. The mean (standard deviation) CHA2DS2-VASc and HAS-BLED risk scores were 2.37 (1.55) and 1.46 (1.18), respectively. Non-vitamin K antagonist oral anticoagulants (62.52%), vitamin K antagonists (22.28%), and antiplatelet therapy (9.85%) were among the prescribed treatments. Rates of transient ischemic attack and all-cause mortality were 2.64% and 0.83%, respectively; all other outcomes (stroke, bleeding, myocardial infarction, systemic embolism) occurred at a rate of ≤ 0.41%. Antithrombotic medications were the major contributors to per-patient total yearly cost (USD 381.2).
Conclusions: The FLOW-AF study showed that patients with NVAF in Egypt are younger and exhibit lower mean baseline CHA2DS2-VASc and HAS-BLED scores compared to Western and other Eastern regions. Additional research, including a broader study population with a longer follow-up, is essential to comprehensively assess the characteristics and outcomes of the NVAF population in Egypt.
心房颤动登记（FLOW-AF）：埃及的患者特征、治疗模式和结果。
在包括埃及在内的中东和北非（MENA）地区，房颤（AF）的真实数据很少。FLOW-AF登记的目的是评估中东和北非地区（包括埃及）新诊断的非瓣膜性心房颤动（NVAF）患者的特征、治疗模式以及临床和经济结果。方法：这项多中心、前瞻性、观察性登记纳入了2020年1月至2022年12月在埃及8个私营医疗保健中心新诊断的非瓣膜性房颤患者。在入组时（基线）收集数据，然后在6个月和12个月的随访中收集数据。基线数据包括人口统计、房颤特征、病史和抗血栓治疗模式。随访数据包括临床事件、医疗资源利用和相关费用。结果：共纳入723例患者。女性占51.87%，平均年龄61.9岁。所有病人都到私营保健部门就诊。平均（标准差）CHA2DS2-VASc和HAS-BLED风险评分分别为2.37（1.55）和1.46（1.18）。非维生素K拮抗剂口服抗凝剂（62.52%）、维生素K拮抗剂（22.28%）和抗血小板治疗（9.85%）属于处方治疗。短暂性脑缺血发作和全因死亡率分别为2.64%和0.83%；所有其他结局（卒中、出血、心肌梗死、全身性栓塞）发生率≤0.41%。抗血栓药物是每位患者年总费用（381.2美元）的主要贡献者。结论：FLOW-AF研究表明，与西方和其他东部地区相比，埃及非瓣瓣性房颤患者更年轻，CHA2DS2-VASc和ha - bled平均基线评分更低。进一步的研究，包括更广泛的研究人群和更长时间的随访，对于全面评估埃及非瓣膜性房颤人群的特征和结果至关重要。
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来源期刊
Cardiology and Therapy
CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
5.30
自引率
0.00%
发文量
38
审稿时长
6 weeks
期刊介绍：
Aims and Scope
Cardiology and Therapy is an international, open access, peer reviewed (single-blind), rapid-publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of cardiovascular therapies and interventions, including devices. Studies relating to diagnosis and diagnostics, pharmacoeconomics, public health, quality of life, as well as patient care, management and education are also encouraged.
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