Is the Effect of Intensive Antihypertensive Treatment in Acute Intracerebral Hemorrhage Dependent on Hematoma Volume? A Traditional Meta-analysis of the Effect of Antihypertensive Regimens, a Bayesian Network Meta-analysis of the Mortality of Antihypertensive Drugs and Systematic Review.

IF 7.4 2区医学 Q1 CLINICAL NEUROLOGY

CNS drugs Pub Date : 2025-05-01 Epub Date: 2025-03-20 DOI:10.1007/s40263-025-01174-8

Cong Li, Lishuai Li, Zhi Li, Kunhang Li, Xin Shi, Yijun Bao

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Abstract

BACKGROUND AND OBJECTIVES: Intensive or conventional antihypertensive treatment for acute intracerebral hemorrhage is still controversial. This study aimed to compare those antihypertensive regimens and analyze the efficacy of antihypertensive drugs.

Methods: Retrieval was conducted through four databases. Meta-analysis and Bayesian network meta-analysis were performed to evaluate the safety of antihypertensive treatments and the efficacy of antihypertensive drugs.

Results: A total of 9271 patients were included. Intensive strategy showed an advantage in 24-h hematoma enlargement (relative risk, RR = 0.76; 95% confidence intervals, CI = 0.67-0.87; P < 0.0001) and 90-day intracranial rebleeding (RR = 0.71, 95% CI = 0.52-0.96, P = 0.03) compared with conventional strategy. Meanwhile, the 90-day renal insufficiency (RR = 2.31, 95% CI = 1.05-5.05, P = 0.04) and renal failure (RR = 2.42, 95% CI = 1.20-4.86, P = 0.01) were increased. When cerebral hematoma volume was less than 15 ml, intensive strategy had a protective effect on 24-h hematoma enlargement (RR = 0.77, 95% CI = 0.67-0.89, P = 0.0003), but it increased 90-day renal failure (RR = 2.33, 95% CI = 1.07-5.04, P = 0.03). For the volume greater than 15 ml, it enhanced 90-day functional independence (RR = 0.78, 95% CI = 0.65-0.94, P = 0.01) and decreased intracranial rebleeding (RR = 0.68, 95% CI = 0.49-0.94, P = 0.02). Labetalol was the best, with the mortality risk probability of 0.09 and the surface under the cumulative ranking curve of 0.33.

Conclusions: This meta-analysis suggests that for intracerebral hematoma volume greater than 15 ml, intensive antihypertensive treatment can improve functional independence and reduce intracranial bleeding. Labetalol has the best effect among the four antihypertensive regimens studied.

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急性脑出血强化降压治疗的效果与血肿量有关吗？降压方案效果的传统meta分析、降压药物死亡率的贝叶斯网络meta分析及系统评价

背景与目的：急性脑出血的强化或常规降压治疗仍存在争议。本研究旨在比较这些降压方案并分析降压药物的疗效。方法：通过四个数据库进行检索。采用meta分析和贝叶斯网络meta分析评价降压治疗的安全性和降压药物的疗效。结果：共纳入9271例患者。强化策略在24小时血肿扩大方面具有优势(相对风险，RR = 0.76；95%置信区间，CI = 0.67-0.87；P < 0.0001)和90天颅内再出血（RR = 0.71, 95% CI = 0.52 ~ 0.96, P = 0.03）。同时，90天肾功能不全（RR = 2.31, 95% CI = 1.05 ~ 5.05, P = 0.04）和肾功能衰竭（RR = 2.42, 95% CI = 1.20 ~ 4.86, P = 0.01）发生率升高。当脑血肿体积小于15 ml时，强化策略对24 h血肿扩大有保护作用（RR = 0.77, 95% CI = 0.67 ~ 0.89, P = 0.0003），但对90 d肾功能衰竭有增加作用（RR = 2.33, 95% CI = 1.07 ~ 5.04, P = 0.03）。对于容量大于15 ml的患者，可增强90天功能独立性（RR = 0.78, 95% CI = 0.65 ~ 0.94, P = 0.01），减少颅内再出血（RR = 0.68, 95% CI = 0.49 ~ 0.94, P = 0.02）。拉贝他洛尔的死亡率风险概率为0.09，累积排序曲线下面为0.33。结论：本荟萃分析提示，对于脑内血肿容量大于15ml的患者，强化降压治疗可改善功能独立性，减少颅内出血。在研究的四种降压方案中，拉贝他洛尔效果最好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS drugs 医学-精神病学

CiteScore

12.00

自引率

3.30%

发文量

审稿时长

6-12 weeks

期刊介绍： CNS Drugs promotes rational pharmacotherapy within the disciplines of clinical psychiatry and neurology. The Journal includes: - Overviews of contentious or emerging issues. - Comprehensive narrative reviews that provide an authoritative source of information on pharmacological approaches to managing neurological and psychiatric illnesses. - Systematic reviews that collate empirical evidence to answer a specific research question, using explicit, systematic methods as outlined by the PRISMA statement. - Adis Drug Reviews of the properties and place in therapy of both newer and established drugs in neurology and psychiatry. - Original research articles reporting the results of well-designed studies with a strong link to clinical practice, such as clinical pharmacodynamic and pharmacokinetic studies, clinical trials, meta-analyses, outcomes research, and pharmacoeconomic and pharmacoepidemiological studies. Additional digital features (including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations) can be published with articles; these are designed to increase the visibility, readership and educational value of the journal’s content. In addition, articles published in CNS Drugs may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand important medical advances.