Cobalt-Catalyzed Remote Site-Selective Hydroboration of Unactivated Alkenes via Chain-Walking Strategy

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-03-11 DOI:10.1021/acs.orglett.5c0033310.1021/acs.orglett.5c00333

Zhiqiang Wang, Mengjie Zhang, Xue Li, Qingqing Xuan* and Qiuling Song*,

引用次数: 0

Abstract

An expedient synthesis of α-aminoboronic acid derivatives via cobalt-catalyzed remote site-selective hydroboration of unactivated alkenes is described herein. The strategy is characterized by its simplicity, site-selectivity, and wide substrate scope, as both terminal and internal alkenes could undergo the reaction smoothly, affording the corresponding products in good yields. According to the mechanism, Co–H is generated from Co(acac)₂ in the presence of HBpin, which starts the chain-walking strategy via a series of alkene insertion and β-H elimination process.

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通过链走策略钴催化非活化烯烃的远程选择性硼氢化反应

本文描述了一种通过钴催化的非活化烯烃的远程选择性硼氢化反应方便地合成α-氨基硼酸衍生物的方法。该策略具有简单、选择性好、底物范围广等特点，终端烯烃和内烯烃均可顺利进行反应，产率高。根据机制，Co - h在HBpin存在下由Co(acac)2生成，HBpin通过一系列的烯烃插入和β-H消除过程开始链走策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.