Chronotype, sleep, and glycemic control in children and adolescents with type 1 diabetes: a case-control study.

IF 1.3 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Pediatric Endocrinology & Metabolism Pub Date : 2025-03-21 DOI:10.1515/jpem-2024-0492

Gulay Can Yilmaz, Mehmet Karadag

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引用次数: 0

Abstract

Objectives: This study aimed to explore the relationships between sleep parameters, chronotype preferences, and glycemic control in children and adolescents with type 1 diabetes (T1DM), compared to healthy peers.

Methods: 96 children and adolescents with T1DM and 95 healthy controls aged 8-18 years participated in this case-control study. Anthropometric measurements were collected, and participants completed the Munich Chronotype Questionnaire and the Pittsburgh Sleep Quality Index (PSQI). Glycemic control was assessed using HbA1c levels.

Results: Children with T1DM demonstrated significantly shorter sleep durations, poorer sleep quality, and a later chronotype compared to controls (p<0.05). Poor glycemic control (HbA1c>7.5 %) was observed in 72.9 % of the T1DM group, with 34.3 % exhibiting very poor control (HbA1c>9 %). Logistic regression identified poor sleep quality (PSQI score, OR: 1.47, p<0.001) and later chronotype (OR: 5.14, p<0.01) as independent predictors of poor glycemic control. Generalized linear modeling (GLM) further revealed significant associations between HbA1c levels, insulin dosage (p<0.001), and chronotype (p=0.090).

Conclusions: Late chronotype and poor sleep quality are closely linked to suboptimal glycemic control in pediatric T1DM populations. These findings underscore the importance of integrating sleep-focused strategies into routine diabetes management.

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儿童和青少年1型糖尿病患者的时间型、睡眠和血糖控制：一项病例对照研究

目的：本研究旨在探讨与健康同龄人相比，儿童和青少年1型糖尿病（T1DM）患者的睡眠参数、时型偏好和血糖控制之间的关系。方法：96例T1DM儿童青少年和95例8-18岁健康对照者参与病例对照研究。收集了人体测量数据，参与者完成了慕尼黑睡眠类型问卷和匹兹堡睡眠质量指数（PSQI）。使用HbA1c水平评估血糖控制。结果：与对照组相比，T1DM患儿的睡眠时间明显缩短，睡眠质量较差，睡眠类型较晚（p7.5 %），其中72.9 %的T1DM组患儿表现出非常差的控制（HbA1c bb0.9 %）。Logistic回归发现睡眠质量差（PSQI评分，OR: 1.47）。结论：晚睡型和睡眠质量差与儿童T1DM人群血糖控制不佳密切相关。这些发现强调了将睡眠策略整合到常规糖尿病管理中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pediatric Endocrinology & Metabolism 医学-内分泌学与代谢

CiteScore

2.70

自引率

7.10%

发文量

176

审稿时长

3-6 weeks

期刊介绍： The aim of the Journal of Pediatric Endocrinology and Metabolism (JPEM) is to diffuse speedily new medical information by publishing clinical investigations in pediatric endocrinology and basic research from all over the world. JPEM is the only international journal dedicated exclusively to endocrinology in the neonatal, pediatric and adolescent age groups. JPEM is a high-quality journal dedicated to pediatric endocrinology in its broadest sense, which is needed at this time of rapid expansion of the field of endocrinology. JPEM publishes Reviews, Original Research, Case Reports, Short Communications and Letters to the Editor (including comments on published papers),. JPEM publishes supplements of proceedings and abstracts of pediatric endocrinology and diabetes society meetings.