The association of plasma TMAO and body composition with the occurrence of PEW in maintenance hemodialysis patients.

IF 3 3区医学 Q1 UROLOGY & NEPHROLOGY

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-03-20 DOI:10.1080/0886022X.2025.2481202

Xinran Wang, Xinyue Peng, Jun Liu, Shiqi Tang, Xinyu Yang, Jianwen Wang

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引用次数: 0

Abstract

Introduction: This study aims to explore the relationship between trimethylamine N-oxide (TMAO), body composition, and protein-energy wasting (PEW) in patients undergoing maintenance hemodialysis (MHD).

Methods: A total of 127 MHD patients participated in this study. Body composition was measured using the InBody770 multi-frequency body composition analyzer. Plasma TMAO concentrations were assessed by ELISA. Cross-sectional analysis was performed after collecting demographic data, dialysis-related data, laboratory parameters, and body composition data from MHD patients.

Results: In MHD patients, the PEW group exhibited lower levels of hemoglobin (Hb), albumin (ALB), transferrin (TF), creatinine (Cr), triglycerides (TG), prealbumin (PALB), soft lean mass (SLM), body mass index (BMI), percent of body fat (PBF), arm muscle circumference (AMC), and phase angle (PHA) compared to the non-PEW group, while C-reactive protein (CRP) and trimethylamine-N-oxide (TMAO) levels, as well as Extracellular Water/Total Body Water (ECW/TBW) ratio, were higher in the PEW group than in the non-PEW group. After full adjustment, TMAO and ECW/TBW ratio were independent risk factors for PEW in MHD patients. Further, plasma TMAO levels correlated negatively with Cr, ALB, Hb, BMI, and PHA, and positively with ECW/TBW in MHD patients with PEW. The ROC curve analysis indicated that the area under the curve (AUC) for plasma TMAO in predicting PEW in MHD patients was 0.788.

Conclusions: Plasma TMAO levels and certain body composition are associated with the occurrence of PEW in MHD patients. Plasma TMAO levels appear to serve as a potential predictive marker for the onset of PEW.

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维持性血液透析患者血浆TMAO和体成分与PEW发生的关系。

简介：本研究旨在探讨维持性血液透析（MHD）患者三甲胺n-氧化物（TMAO）、身体成分和蛋白质-能量消耗（PEW）之间的关系。方法：共127例MHD患者参与本研究。采用InBody770多频身体成分分析仪测定身体成分。ELISA法测定血浆TMAO浓度。在收集MHD患者的人口统计数据、透析相关数据、实验室参数和身体成分数据后进行横断面分析。结果:在MHD患者中，与非PEW组相比，PEW组表现出较低的血红蛋白（Hb）、白蛋白（ALB）、转铁蛋白（TF）、肌酐（Cr）、甘油三酯（TG）、前白蛋白（PALB）、软瘦质量（SLM）、体重指数（BMI）、体脂百分比（PBF）、手臂肌肉周长（AMC）和相位角（PHA）水平，而c反应蛋白（CRP）和三甲胺- n-氧化物（TMAO）水平，以及细胞外水/全身水（ECW/TBW）比。在皮尤研究中心的小组中比在非皮尤研究中心的小组中要高。完全调整后，TMAO和ECW/TBW比值是MHD患者皮尤的独立危险因素。此外，MHD合并PEW患者血浆TMAO水平与Cr、ALB、Hb、BMI和PHA呈负相关，与ECW/TBW呈正相关。ROC曲线分析显示，血浆TMAO预测MHD患者皮尤的曲线下面积（AUC）为0.788。结论：血浆TMAO水平和某些体成分与MHD患者发生PEW有关。血浆TMAO水平似乎可以作为PEW发病的潜在预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Renal Failure 医学-泌尿学与肾脏学

CiteScore

3.90

自引率

13.30%

发文量

374

审稿时长

1 months

期刊介绍： Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.