{"title":"mSphere of Influence: The integral art of resolving host-virus interactions.","authors":"Elliott D SoRelle","doi":"10.1128/msphere.01040-24","DOIUrl":null,"url":null,"abstract":"<p><p>Elliott D. SoRelle studies viral infection and pathogenesis, specifically Epstein-Barr virus and its associated diseases, through the lens of single cell and spatial biology. In this mSphere of Influence article, he reflects on the essential value of art in biological research-and the frequent homology between the two. He incorporates themes from music and visual arts into a discussion of how three publications entitled \"The cybernetics of development\" by C. H. Waddington (<i>The Strategy of the Genes</i>, chapter 2, https://doi.org/10.4324/9781315765471), \"Epstein-Barr viral productive amplification reprograms nuclear architecture, DNA replication, and histone deposition\" by Y.-F. Chiu et al. (Cell Host Microbe 14:607-618, 2013, 10.1016/j.chom.2013.11.009), and \"Comprehensive integration of single-cell data\" by T. Stuart et al. (Cell 177:1888-1902.e21, 2019, https://doi.org/10.1016/j.cell.2019.05.031) shape his scientific perspectives in single-cell virology and provide a conceptual framework for dissecting multifaceted host-virus interactions.</p>","PeriodicalId":19052,"journal":{"name":"mSphere","volume":" ","pages":"e0104024"},"PeriodicalIF":3.7000,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"mSphere","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1128/msphere.01040-24","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Elliott D. SoRelle studies viral infection and pathogenesis, specifically Epstein-Barr virus and its associated diseases, through the lens of single cell and spatial biology. In this mSphere of Influence article, he reflects on the essential value of art in biological research-and the frequent homology between the two. He incorporates themes from music and visual arts into a discussion of how three publications entitled "The cybernetics of development" by C. H. Waddington (The Strategy of the Genes, chapter 2, https://doi.org/10.4324/9781315765471), "Epstein-Barr viral productive amplification reprograms nuclear architecture, DNA replication, and histone deposition" by Y.-F. Chiu et al. (Cell Host Microbe 14:607-618, 2013, 10.1016/j.chom.2013.11.009), and "Comprehensive integration of single-cell data" by T. Stuart et al. (Cell 177:1888-1902.e21, 2019, https://doi.org/10.1016/j.cell.2019.05.031) shape his scientific perspectives in single-cell virology and provide a conceptual framework for dissecting multifaceted host-virus interactions.
Elliott D. SoRelle通过单细胞和空间生物学的视角研究病毒感染和发病机制，特别是eb病毒及其相关疾病。在这篇影响范围的文章中，他反思了艺术在生物学研究中的基本价值，以及两者之间频繁的同源性。他结合了音乐和视觉艺术的主题，讨论了C. H. Waddington的《发展的控制论》（《基因的策略》第2章，https://doi.org/10.4324/9781315765471）、Y.-F.的《爱泼斯坦-巴尔病毒生产扩增法》对核结构、DNA复制和组蛋白沉积的重编程。Chiu et al. (Cell Host microbiology, 14:607-618, 2013, 10.1016/j.c om.2013.11.009)， T. Stuart et al. （Cell 177:1888-1902）“单细胞数据的综合集成”。E21, 2019, https://doi.org/10.1016/j.cell.2019.05.031)塑造了他在单细胞病毒学方面的科学观点，并为剖析多方面的宿主-病毒相互作用提供了一个概念框架。
期刊介绍：
mSphere™ is a multi-disciplinary open-access journal that will focus on rapid publication of fundamental contributions to our understanding of microbiology. Its scope will reflect the immense range of fields within the microbial sciences, creating new opportunities for researchers to share findings that are transforming our understanding of human health and disease, ecosystems, neuroscience, agriculture, energy production, climate change, evolution, biogeochemical cycling, and food and drug production. Submissions will be encouraged of all high-quality work that makes fundamental contributions to our understanding of microbiology. mSphere™ will provide streamlined decisions, while carrying on ASM''s tradition for rigorous peer review.
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