Oncogenic and tumor-suppressive roles of Lipocalin 2 (LCN2) in tumor progression.

IF 4.1 4区医学 Q3 ONCOLOGY

Oncology Research Pub Date : 2025-02-28 eCollection Date: 2025-01-01 DOI:10.32604/or.2024.051672

Baoxing Huang, Zichang Jia, Chenchen Fu, Moxian Chen, Zezhuo Su, Yunsheng Chen

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引用次数: 0

Abstract

Lipocalin-2 (LCN2) is a member of the lipocalin superfamily with multiple functions and can participate in the transport of a variety of small lipophilic ligands in vivo. LCN2 is significantly expressed in various tumors and plays an important role in regulating tumor cell proliferation, invasion, and metastasis. The specific actions of LCN2 in tumors may vary depending on the particular type of cancer involved. In this review, we provide an extensive overview of the transcriptional and post-transcriptional regulation of LCN2 in health and disease. Furthermore, we summarize the impact of LCN2 dysregulation in a broad range of tumors. Lastly, we examine the mechanisms of action of LCN2 during tumorigenesis, progression, and metastasis. Understanding the complex relationships between LCN2 and tumor development, progression, and metastasis is vital for advancing our knowledge of cancer biology, developing biomarkers for diagnosis and clinical decision-making, and creating therapeutic strategies to improve the management of patients with cancer.

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脂钙蛋白2 （LCN2）在肿瘤进展中的致癌和抑瘤作用。

脂载蛋白2 （lipocalin -2, LCN2）是脂载蛋白超家族的一员，具有多种功能，在体内可参与多种小亲脂配体的转运。LCN2在多种肿瘤中显著表达，在调节肿瘤细胞增殖、侵袭和转移中发挥重要作用。LCN2在肿瘤中的具体作用可能因所涉及的特定癌症类型而异。在这篇综述中，我们提供了LCN2在健康和疾病中的转录和转录后调控的广泛概述。此外，我们总结了LCN2失调在广泛的肿瘤中的影响。最后，我们研究了LCN2在肿瘤发生、进展和转移中的作用机制。了解LCN2与肿瘤发生、进展和转移之间的复杂关系，对于提高我们对癌症生物学的认识，开发诊断和临床决策的生物标志物，以及制定治疗策略以改善癌症患者的管理至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncology Research 医学-肿瘤学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Oncology Research Featuring Preclinical and Clincal Cancer Therapeutics publishes research of the highest quality that contributes to an understanding of cancer in areas of molecular biology, cell biology, biochemistry, biophysics, genetics, biology, endocrinology, and immunology, as well as studies on the mechanism of action of carcinogens and therapeutic agents, reports dealing with cancer prevention and epidemiology, and clinical trials delineating effective new therapeutic regimens.