Amyloidosis of the heart: pathophysiology, diagnosis and treatment.

Abstract

Introduction: Cardiacamyloidosis is characterized by amyloid fibril aggregation due tomisfolded circulating proteins and their deposition in the heart,leading to cardiac damage and dysfunction. Given cardiac amyloidosisis associated with a poor prognosis without treatment, earlydiagnosis and management are critical to increase survival from thedisease.

Areascovered: Thisarticle provides an overview of the disease process, diagnosticmodalities, and therapies for cardiac amyloidosis.

Expertopinion: Recenttechnological advances have led to the development of reliable andaccurate diagnostic modalities for identifying cardiac amyloidosis.Recent introduction of novel disease-modifying therapies for cardiacamyloidosis have resulted in improvements in the management andprognosis of the disease.