Fabrication of micro-wire stent electrode as a minimally invasive endovascular neural interface for vascular electrocorticography using laser ablation method.

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Bo Wen, Lu Su, Yuan Zhang, Aiping Wang, Hongchen Zhao, Jianjun Wu, Zhongxue Gan, Lihua Zhang, Xiaoyang Kang
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引用次数: 0

Abstract

Objective. Minimally invasive endovascular stent electrode is a currently emerging technology in neural engineering with minimal damage to the neural tissue. However, the typical stent electrode still requires resistive welding and is relatively large, limiting its application mainly on the large animal or thick vessels. In this study, we investigated the feasibility of laser ablation of micro-wire stent electrode with a diameter as small as 25μmand verified it in the superior sagittal sinus (SSS) of a rat.Approach. We have developed a laser ablation technology to expose the electrode sites of the micro-wire on both sides without damaging the wire itself. During laser ablation, we applied a new method to fix and realign the micro-wires. The micro-wire stent electrode was fabricated by carefully assemble the micro-wire and stent. We tested the electrochemical performances of the electrodes as a neural interface. Finally, we deployed the stent electrode in a rat to verified the feasibility.Main result. Based on the proposed micro-wire stent electrode, we demonstrated that the stent electrode could be successfully deployed in a rat. With the benefit of the smaller design and laser fabrication technology, it can be fitted into a catheter with an inner diameter of 0.6mm. The vascular electrocorticography can be detected during the acute recording, making it promising in the application of small animals and thin vessels.Significance. The method we proposed combines the advantages of endovascular micro-wire electrode and stent, helping make the electrodes smaller. This study provided an alternative method for deploying micro-wire electrodes into thinner vessels as an endovascular neural interface.

激光消融法制备用于血管皮质电成像的微创血管内神经接口微丝支架电极。
目的:微创血管内支架电极是目前神经工程中新兴的一种对神经组织损伤最小的技术。然而,典型的支架电极仍需要电阻焊接且体积较大,限制了其主要应用于大型动物或厚血管。在这项研究中,我们研究了激光消融直径小于25 μm的微丝支架电极的可行性,并在大鼠上矢状窦(SSS)上进行了验证。方法:我们开发了一种激光消融技术,可以在不损伤微丝本身的情况下暴露微丝两侧的电极位置。在激光烧蚀过程中,我们采用了一种新的方法来固定和调整微丝。将微丝与支架精心组装,制成微丝支架电极。我们测试了电极作为神经界面的电化学性能。最后,我们在大鼠身上展开支架电极,验证了支架电极的可行性。 ;主要结果:基于所提出的微丝支架电极,我们证明了支架电极可以在大鼠身上成功展开。得益于更小的设计和激光制造技术,它可以安装在内径为0.6毫米的导管中。血管皮质电图可在急性记录过程中检测到,在小动物和薄血管中应用前景广阔。意义:我们提出的方法结合了血管内微丝电极和支架的优点,有助于使电极更小。本研究提供了一种将微丝电极置入较薄血管作为血管内神经界面的替代方法。
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来源期刊
Biomedical Physics & Engineering Express
Biomedical Physics & Engineering Express RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.80
自引率
0.00%
发文量
153
期刊介绍: BPEX is an inclusive, international, multidisciplinary journal devoted to publishing new research on any application of physics and/or engineering in medicine and/or biology. Characterized by a broad geographical coverage and a fast-track peer-review process, relevant topics include all aspects of biophysics, medical physics and biomedical engineering. Papers that are almost entirely clinical or biological in their focus are not suitable. The journal has an emphasis on publishing interdisciplinary work and bringing research fields together, encompassing experimental, theoretical and computational work.
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