Understanding gold nanoparticles and their attributes in ovarian cancer therapy

IF 27.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cancer Pub Date : 2025-03-20 DOI:10.1186/s12943-025-02280-3

Rishabh Aggarwal, Afsana Sheikh, Masheera Akhtar, Mohammed Ghazwani, Umme Hani, Amirhossein Sahebkar, Prashant Kesharwani

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Abstract

Ovarian cancer is one the deadliest disease wherein the survival rate is very low. Despite of advances in medical sciences, researches are still at the stage of infancy where patients are succumbing to this malignancy. Multidrug resistance, toxicity, mode of treatment related issues like catheter related complication poises a number of challenges to scientists worldwide. Novel therapy is now thus being focussed to sensitive the cells more towards the treatment. Gold nanoparticles (Au NPs), known for their high biocompatibility, and strong optical and magnetic responses, have emerged as promising agents for both the diagnosis and treatment of ovarian cancer. Owing to physical characteristics, AuNPs may be used as adjuvants in bioimaging, radiotherapy and fluorescence imaging. As a result, these characteristics substantially support AuNPs in biological domains. In addition to their therapeutic potential, Au NPs exhibit strong surface plasmon resonance (SPR) properties, enhancing imaging techniques for early detection of ovarian tumors. Furthermore, chemical properties such as Magnetic Resonance and Imaging Properties, X-ray imaging property, Two-photon or multiphoton imaging, and Optical coherence tomography (OCT) imaging properties enhance the use of Au NPs in diagnosis. This paper highlights the properties, targeting potential and diagnosis and treatment of ovarian cancer by Au NPs has been discussed.

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了解金纳米颗粒及其在卵巢癌治疗中的特性

卵巢癌是最致命的疾病之一，其存活率非常低。尽管医学科学取得了进步，但研究仍处于初级阶段，患者正在屈服于这种恶性肿瘤。多药耐药、毒性、治疗方式等与导管相关的并发症等问题给全世界的科学家带来了许多挑战。因此，新的治疗方法正在集中于使细胞对治疗更加敏感。金纳米颗粒（Au NPs）以其高生物相容性和强光学和磁反应而闻名，已成为卵巢癌诊断和治疗的有希望的药物。由于其物理特性，AuNPs可作为生物成像、放射治疗和荧光成像的佐剂。因此，这些特征实质上支持生物领域的aunp。除了具有治疗潜力外，Au NPs还表现出强烈的表面等离子体共振（SPR）特性，增强了卵巢肿瘤早期检测的成像技术。此外，诸如磁共振和成像性质、x射线成像性质、双光子或多光子成像以及光学相干断层扫描（OCT）成像性质等化学性质增强了Au NPs在诊断中的应用。本文重点讨论了Au NPs的性质、靶向潜力及卵巢癌的诊断和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

期刊介绍： Molecular Cancer is a platform that encourages the exchange of ideas and discoveries in the field of cancer research, particularly focusing on the molecular aspects. Our goal is to facilitate discussions and provide insights into various areas of cancer and related biomedical science. We welcome articles from basic, translational, and clinical research that contribute to the advancement of understanding, prevention, diagnosis, and treatment of cancer. The scope of topics covered in Molecular Cancer is diverse and inclusive. These include, but are not limited to, cell and tumor biology, angiogenesis, utilizing animal models, understanding metastasis, exploring cancer antigens and the immune response, investigating cellular signaling and molecular biology, examining epidemiology, genetic and molecular profiling of cancer, identifying molecular targets, studying cancer stem cells, exploring DNA damage and repair mechanisms, analyzing cell cycle regulation, investigating apoptosis, exploring molecular virology, and evaluating vaccine and antibody-based cancer therapies. Molecular Cancer serves as an important platform for sharing exciting discoveries in cancer-related research. It offers an unparalleled opportunity to communicate information to both specialists and the general public. The online presence of Molecular Cancer enables immediate publication of accepted articles and facilitates the presentation of large datasets and supplementary information. This ensures that new research is efficiently and rapidly disseminated to the scientific community.