Probabilistic approach for estimation of binding rate constants for clusters of targets.

IF 2.2 3区 物理与天体物理 Q2 PHYSICS, FLUIDS & PLASMAS
Boris P Belotserkovskii
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引用次数: 0

Abstract

The binding rate constant for a target within a cluster of targets is smaller than for an isolated target due to competition between the targets; and the magnitude of this decrease in the binding rate constant depends upon the shape and the size of the cluster. We obtain a general formula for binding rate constants for clusters of arbitrary shapes and sizes using an approach based upon probabilities to visit a certain domain in space by a searching particle. We applied this result to various shapes of clusters including a spherical shell, a straight line, a random coil, and a random "cloud." Our results could be applicable for targets localized on natural and artificial particles (e.g., receptors on the surfaces of living cells, and macro- and small molecules attached to magnetic beads) and to the target localized on polymers (e.g., DNA or RNA).

一种估计目标簇结合速率常数的概率方法。
由于靶标之间的竞争,在一簇靶标中单个靶标的结合速率常数比孤立靶标的结合速率常数小;结合速率常数下降的幅度取决于团簇的形状和大小。我们使用基于搜索粒子在空间中访问某一区域的概率的方法,得到了任意形状和大小的簇的结合速率常数的一般公式。我们将这一结果应用于各种形状的星团,包括球形外壳、直线、随机线圈和随机“云”。我们的结果可以适用于定位在天然和人工颗粒上的靶标(例如,活细胞表面的受体,附着在磁珠上的大分子和小分子)和定位在聚合物上的靶标(例如,DNA或RNA)。
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来源期刊
Physical Review E
Physical Review E PHYSICS, FLUIDS & PLASMASPHYSICS, MATHEMAT-PHYSICS, MATHEMATICAL
CiteScore
4.50
自引率
16.70%
发文量
2110
期刊介绍: Physical Review E (PRE), broad and interdisciplinary in scope, focuses on collective phenomena of many-body systems, with statistical physics and nonlinear dynamics as the central themes of the journal. Physical Review E publishes recent developments in biological and soft matter physics including granular materials, colloids, complex fluids, liquid crystals, and polymers. The journal covers fluid dynamics and plasma physics and includes sections on computational and interdisciplinary physics, for example, complex networks.
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